Organophosphate (OP) chemicals include pesticides such as parathion, and nerve gases
such as sarin and soman and are considered major chemical threat agents. Acute OP …

Organophosphorus agents, also known as nerve agents, are very dangerous chemicals that
were used as chemical warfare agents. HI-6 is one of the most promising reactivators which …

Organophosphorus (OP) compounds are deadly chemicals that exert their intoxicating
effects through the irreversible inhibition of acetylcholinesterase (AChE). In addition to an …

Organophosphorus nerve agents pose a global threat to both military personnel and civilian
population, because of their high acute toxicity and insufficient medical countermeasures …

Benzodiazepines are the primary treatment option for organophosphate (OP)-induced status
epilepticus (SE), but these antiseizure drugs (ASDs) lose efficacy as treatment is delayed. In …

We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE)
reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) …

Memantine is the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, used
in the treatment of Alzheimer's disease. It is also known that memantine pretreatment …

Amyotrophic lateral sclerosis (ALS) is a degenerative disorder affecting motor neurons in the
neocortex, brainstem, and spinal cord. About 10% of ALS cases can be related to genetic …

The propensity to induce central effects depends on the Organophosphorus pesticide and its
ability to induce them before life-threatening peripheral effects start, especially respiratory …