[HTML][HTML] Ankylosing spondylitis: etiology, pathogenesis, and treatments
Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …
The gut-joint axis in spondyloarthritis: immunological, microbial, and clinical insights
Z Qaiyum, M Lim, RD Inman - Seminars in Immunopathology, 2021 - Springer
The strong genetic and clinical overlaps between spondyloarthritis (SpA) and inflammatory
bowel disease (IBD) have placed much needed focus on the gut-joint axis of inflammation in …
bowel disease (IBD) have placed much needed focus on the gut-joint axis of inflammation in …
Dual neutralisation of interleukin-17A and interleukin-17F with bimekizumab in patients with active ankylosing spondylitis: results from a 48-week phase IIb …
D Van Der Heijde, LS Gensler, A Deodhar… - Annals of the …, 2020 - ard.bmj.com
Objectives Bimekizumab selectively neutralises both interleukin (IL)-17A and IL-17F. We
report efficacy and safety in a phase IIb dose-ranging study in patients with active ankylosing …
report efficacy and safety in a phase IIb dose-ranging study in patients with active ankylosing …
Immune-related adverse events (irAEs) in ankylosing spondylitis (AS) patients treated with interleukin (IL)-17 inhibitors: a systematic review and meta-analysis
H Azadeh, R Alizadeh-Navaei, A Rezaiemanesh… - …, 2022 - Springer
Background Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease
characterized by immune system dysregulation and inflammation in the joints. Interleukin …
characterized by immune system dysregulation and inflammation in the joints. Interleukin …
[HTML][HTML] Imbalance of peripheral lymphocyte subsets in patients with ankylosing spondylitis: A meta-analysis
D Liu, B Liu, C Lin, J Gu - Frontiers in Immunology, 2021 - frontiersin.org
Ankylosing spondylitis is a complicated consequence of genetic predisposition and
environmental factors. Enthesitis is believed to be the hallmark of ankylosing spondylitis …
environmental factors. Enthesitis is believed to be the hallmark of ankylosing spondylitis …
A novel signature of interleukins 36α, 37, 38, 39 and 40 in ankylosing spondylitis
AS Jaber, AH Ad'hiah - Cytokine, 2023 - Elsevier
The current study examined five cytokines, three belong to interleukin (IL)-1 family (IL-36α, IL-
37 and IL-38), one belongs to IL-12 family (IL-39) and one has not been assigned to a family …
37 and IL-38), one belongs to IL-12 family (IL-39) and one has not been assigned to a family …
[HTML][HTML] Role of innate immune system in the pathogenesis of ankylosing spondylitis
Ankylosing Spondylitis (AS) is a debilitating rheumatic disease that gives young adults a
severe form of arthritis with pain and stiffness in the axial skeleton. After the discovery of …
severe form of arthritis with pain and stiffness in the axial skeleton. After the discovery of …
[HTML][HTML] Integrative single-cell RNA-seq and ATAC-seq analysis of peripheral mononuclear cells in patients with ankylosing spondylitis
H Xu, H Yu, L Liu, H Wu, C Zhang, W Cai… - Frontiers in …, 2021 - frontiersin.org
Objective Genetic studies on ankylosing spondylitis (AS) have identified more than 100
pathogenic genes. Building a bridge between these genes and biologically targeted …
pathogenic genes. Building a bridge between these genes and biologically targeted …
Optimal Biologic Drugs for the Treatment of Ankylosing Spondylitis: Results from a Network Meta‐Analysis and Network Metaregression
Z Cao, J Guo, Q Li, Y Li, J Wu - BioMed Research International, 2022 - Wiley Online Library
Background. Ankylosing spondylitis (AS) is a common immune‐related systemic chronic
inflammatory osteoarthropathy. Previous studies have proven that biologic agents, including …
inflammatory osteoarthropathy. Previous studies have proven that biologic agents, including …
[HTML][HTML] How has molecular biology enhanced our undertaking of axSpA and its management
M Fatica, A D'Antonio, L Novelli, P Triggianese… - Current rheumatology …, 2023 - Springer
Purpose This review aims at investigating pathophysiological mechanisms in
spondyloarthritis (SpA). Analysis of genetic factors, immunological pathways, and …
spondyloarthritis (SpA). Analysis of genetic factors, immunological pathways, and …