Methods for depositing thin films are important in generating functional materials for diverse
applications in a wide variety of fields. Over the last half-century, the layer-by-layer assembly …

Microfluidic chip technology is an emerging tool in the field of biomedical application.
Microfluidic chip includes a set of groves or microchannels that are engraved on different …

The dismal success rate of clinical trials for Alzheimer's disease (AD) motivates us to
develop model systems of AD pathology that have higher predictive validity. The advent of …

Hepatology and drug development for liver diseases require in vitro liver models. Typical
models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte …

This review covers several aspects of microfluidic devices used for culturing and monitoring
of both adherent and non-adherent cells, including a multitude of applications. A comparison …

In the body, cells inhabit within a complex three-dimensional (3D) extracellular matrix that
provides physical and chemical signals to regulate the cell fate. Cultured cells in Petri dishes …

A growing number of failing clinical trials for cancer therapy are substantiating the need to
upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in …

Even as biomedical science has advanced dramatically, concerns have arisen regarding the
cost and efficiency of translating these advances into safe and efficacious new drugs. Two …

Highlights•Characteristics of the tumor microenvironment that have to be considered for the
development of 3D cell spheroid model systems for translational cancer research.•Methods …

In this study we used differentiated adult human upcyte® cells for the in vitro generation of
liver organoids. Upcyte® cells are genetically engineered cell strains derived from primary …