Exercise has multiple beneficial effects on health including decreasing the risk of
neurodegenerative diseases. Such effects are thought to be mediated (at least in part) by …

Accumulating evidence supports that physical exercise (EX) is the most effective non-
pharmacological strategy to improve brain health. EX prevents cognitive decline associated …

A pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-β (Aβ)
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …

Postoperative cognitive dysfunction (POCD) is a severe neurological complication after
anesthesia and surgery. However, there is still a lack of effective clinical pharmacotherapy …

Diabetes mellitus is associated with cognitive impairment characterized by memory loss and
cognitive inflexibility. Recent studies have revealed that ChemR23 is implicated in both …

Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with insulin resistance
and hyperglycemia. Chronic exposure to a T2DM microenvironment with hyperglycemia …

First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …

Cognitive dysfunction often occurs in diabetes mellitus patients. This study aimed to
investigate the efficacy of melatonin (MLT) in improving diabetes‐associated cognitive …

Depression is the most prevalent psychiatric disorder experienced by the world's population.
Mechanisms associated with depression-like behavior have not been fully investigated …

Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle
is not beneficial to health. Exercise can promote many enabling pathways, particularly …