MYB transcription factors are encoded by a large family of highly conserved genes from
plants to vertebrates. There are three members of the MYB gene family in human, namely …

Abstract Osteopontin (OPN), a senescence‐associated secretory phenotype factor, is
increased in patients with nonalcoholic fatty liver disease (NAFLD). Cellular senescence has …

The basic leucine zipper transcription factor ATF5 is overexpressed in many tumor types and
interference with its expression or function inhibits cancer cell survival. As a potential …

Simple Summary Cellular senescence is a defensive response of cells to external stresses
and occurs in a wide range of physiological and pathological processes, including …

Objective The objective was to assess the proportion of Th1, Th2 and Th17 phenotypes in
senescent CD4+ CD28null cells from patients with systemic lupus erythematosus (SLE) and …

Background Prolonged exposure to the senescence-associated secretory phenotype
(SASP) with age leads to chronic low-grade inflammation in neighboring cells and tissues …

Aging is an intricate process characterized by multiple hallmarks including stem cell
exhaustion, genome instability, epigenome alteration, impaired proteostasis, and cellular …

A central hallmark of aging is the accumulation of senescent cells. Cellular senescence is a
state of permanent cell-cycle arrest induced by the DNA Damage Response (DDR) as a …

Abstract The INhibitor of Growth (ING) family of proteins was initially characterized in 1996
when subtractive hybridization studies revealed a novel type II tumor suppressor, which the …

Nádorové mikroprostředí glioblastomu (GB) je velice komplexní a dále se mění při
radioterapii a chemoterapii způsobem, který podporuje maligní vlastnosti glioblastomu …