The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

Chronic exposure to uncontrollable stress causes loss of spines and dendrites in the
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …

The three sets of symptoms associated with schizophrenia—positive, negative, and
cognitive—are burdensome and have serious effects on public health, which affects up to …

There is a consensus in the field that microglia play a prominent role in neurodevelopmental
processes like synaptic pruning and neuronal network maturation. Thus, a current …

Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a
dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of …

Importance Biomarkers that are predictive of outcomes in individuals at risk of psychosis
would facilitate individualized prognosis and stratification strategies. Objective To …

Early identification and treatment significantly improve clinical outcomes of psychotic
disorders. Recent studies identified protein components of the complement and coagulation …

The investigation of immune system abnormalities in schizophrenia, although ongoing for
decades, has become a popular area of research. The authors present a selected review of …

The mammalian gut contains a large, complex community of microorganisms collectively
termed the microbiota. It is increasingly appreciated that gut microbes are closely integrated …

To date, microglia subsets in the healthy CNS have not been identified. Utilizing
autofluorescence (AF) as a discriminating parameter, we identified two novel microglia …