Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …

Although macroautophagy deficits are implicated across adult-onset neurodegenerative
diseases, we understand little about how the discrete, highly evolved cell types of the central …

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …

Parkinson's disease (PD) is a progressive disorder that belongs to a class of
neurodegenerative disorders (NDs) called Synucleinopathies. It has characterized by the …

PTEN-induced kinase 1 (PINK1)-mediated mitophagy and caspase-1/gasdermin D
canonical pyroptosis pathways have been implicated in the pathogenesis of postoperative …

Autophagy degrades phagocytosed damaged organelles, misfolded proteins, and various
pathogens through lysosomes as an essential way to maintain cellular homeostasis …

Background and Purpose Ischaemia–reperfusion (I/R) injury is a major contributor to skin
flap necrosis, which presents a challenge in achieving satisfactory therapeutic outcomes …

Background Inflammasomes in astrocytes have been shown to play a crucial role in the
pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD) and …

Oligodendrocytes are the sole myelin-producing cells in the central nervous system.
Oligodendrocyte number is tightly controlled across diverse brain regions to match local …