Hallmarks of neurodegenerative diseases
DM Wilson, MR Cookson, L Van Den Bosch… - Cell, 2023 - cell.com
Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing
Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …
changes in both intracellular and extracellular microenvironments that affect the entire body …
Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death
ER Aber, CJ Griffey, T Davies, AM Li, YJ Yang… - Cell reports, 2022 - cell.com
Although macroautophagy deficits are implicated across adult-onset neurodegenerative
diseases, we understand little about how the discrete, highly evolved cell types of the central …
diseases, we understand little about how the discrete, highly evolved cell types of the central …
Protein homeostasis in aging and cancer
XQ Chen, T Shen, SJ Fang, XM Sun, GY Li… - Frontiers in Cell and …, 2023 - frontiersin.org
Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …
or proteostasis, is a universal hallmark of both the aging process and cancer, a …
[HTML][HTML] Targeted protein degradation for the treatment of Parkinson's disease: Advances and future perspective
R Amirian, MA Badrbani, H Derakhshankhah… - Biomedicine & …, 2023 - Elsevier
Parkinson's disease (PD) is a progressive disorder that belongs to a class of
neurodegenerative disorders (NDs) called Synucleinopathies. It has characterized by the …
neurodegenerative disorders (NDs) called Synucleinopathies. It has characterized by the …
Inhibition of PINK1-mediated Mitophagy contributes to postoperative cognitive dysfunction through activation of Caspase-3/GSDME-dependent pyroptosis
W Wang, B Zhao, W Gao, W Song, J Hou… - ACS Chemical …, 2023 - ACS Publications
PTEN-induced kinase 1 (PINK1)-mediated mitophagy and caspase-1/gasdermin D
canonical pyroptosis pathways have been implicated in the pathogenesis of postoperative …
canonical pyroptosis pathways have been implicated in the pathogenesis of postoperative …
Interaction between autophagy and the NLRP3 inflammasome in Alzheimer's and Parkinson's disease
R Lu, L Zhang, X Yang - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Autophagy degrades phagocytosed damaged organelles, misfolded proteins, and various
pathogens through lysosomes as an essential way to maintain cellular homeostasis …
pathogens through lysosomes as an essential way to maintain cellular homeostasis …
A snake cathelicidin enhances transcription factor EB‐mediated autophagy and alleviates ROS‐induced pyroptosis after ischaemia–reperfusion injury of island skin …
N Yang, G Yu, Y Lai, J Zhao, Z Chen… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Ischaemia–reperfusion (I/R) injury is a major contributor to skin
flap necrosis, which presents a challenge in achieving satisfactory therapeutic outcomes …
flap necrosis, which presents a challenge in achieving satisfactory therapeutic outcomes …
Targeting CB2R in astrocytes for Parkinson's disease therapy: unraveling the Foxg1-mediated neuroprotective mechanism through autophagy-mediated NLRP3 …
H Zhu, F Xiao, Y Xiao, Y Guo, X Shan, Z Zhang… - Journal of …, 2023 - Springer
Background Inflammasomes in astrocytes have been shown to play a crucial role in the
pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD) and …
pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD) and …
[HTML][HTML] Autophagy collaborates with apoptosis pathways to control oligodendrocyte number
Oligodendrocytes are the sole myelin-producing cells in the central nervous system.
Oligodendrocyte number is tightly controlled across diverse brain regions to match local …
Oligodendrocyte number is tightly controlled across diverse brain regions to match local …