[HTML][HTML] Triple negative breast cancer treatment options and limitations: future outlook

O Obidiro, G Battogtokh, EO Akala - Pharmaceutics, 2023 - mdpi.com
Triple negative breast cancer (TNBC) has a negative expression of estrogen receptors (ER),
progesterone receptors (PR), and human epidermal growth factor receptors (HER2). The …

[HTML][HTML] Genetic heterogeneity, tumor microenvironment and immunotherapy in triple-negative breast cancer

E Kudelova, M Smolar, V Holubekova… - International Journal of …, 2022 - mdpi.com
Heterogeneity of triple-negative breast cancer is well known at clinical, histopathological,
and molecular levels. Genomic instability and greater mutation rates, which may result in the …

[HTML][HTML] Prevalence of cobalt in the environment and its role in biological processes

G Genchi, G Lauria, A Catalano, A Carocci… - Biology, 2023 - mdpi.com
Simple Summary Cobalt (Co) is an essential element with ubiquitous dietary exposure and
possible incremental exposure due to dietary supplements, occupations, and medical …

[HTML][HTML] Are nutraceuticals effective in COVID-19 and post-COVID prevention and treatment?

A Catalano, D Iacopetta, J Ceramella, ACD Maio… - Foods, 2022 - mdpi.com
The beginning of the end or the end of the beginning? After two years mastered by
coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. The …

Beyond cisplatin: New frontiers in metallodrugs for hard-to-treat triple negative breast cancer

N Muhammad, M Hanif, P Yang - Coordination Chemistry Reviews, 2024 - Elsevier
Triple-negative breast cancer (TNBC) is the most aggressive and hard-to-treat form of breast
cancer. TNBC has a higher propensity for earlier relapse and an increased risk of metastasis …

[HTML][HTML] Impact of cytochrome P450 enzymes on the phase I metabolism of drugs

D Iacopetta, J Ceramella, A Catalano, E Scali… - Applied Sciences, 2023 - mdpi.com
The cytochrome P450 (CYP) enzyme family is the major enzyme system catalyzing the
phase I metabolism of xenobiotics, including pharmaceuticals and toxic compounds in the …

[HTML][HTML] Neuroprotective Effects of Curcumin in Neurodegenerative Diseases

G Genchi, G Lauria, A Catalano, A Carocci… - Foods, 2024 - mdpi.com
Curcumin, a hydrophobic polyphenol extracted from the rhizome of Curcuma longa, is now
considered a candidate drug for the treatment of neurological diseases, including …

[HTML][HTML] Exogenous hydrogen sulfide (H2S) exerts therapeutic potential in triple-negative breast cancer by affecting cell cycle and DNA replication pathway

X Cui, R Liu, L Duan, Q Zhang, D Cao… - Biomedicine & …, 2023 - Elsevier
Triple negative breast cancer (TNBC) is a highly aggressive subtype with a poor prognosis
due to its high rates of proliferation and metastasis. Recently, hydrogen sulfide (H 2 S) has …

Enantioselective construction of dihydropyranone-fused indoles by [3+ 3] annulation of in situ-derived indolin-3-ones and unsaturated carboxylic esters

H Wang, Q Zhang, S Xiao, G Wang, X Huang… - Organic Chemistry …, 2023 - pubs.rsc.org
We have developed an N-heterocyclic carbene (NHC) and base-mediated [3+ 3] annulation
reaction of unsaturated carboxylic esters and sulfonium salts for rapid and direct access to …

Gallic acid‐loaded chitosan nanoparticles enhance the DNA damage and apoptotic features through inhibiting flap endonuclease‐1 in triple‐negative breast cancer …

M Velaiyan, R Muthusamy, M Kativa… - Environmental …, 2024 - Wiley Online Library
This study investigated the fabrication of gallic acid‐loaded chitosan nanoparticles (Gal‐Chi‐
NPs) that enhanced the DNA damage and apoptotic features by inhibiting FEN‐1 …