Identification of potent anticancer agents with high selectivity and low toxicity remains on the
way to human health. Pyridazine featuring advantageous physicochemical properties and …

Phthalazine, a structurally and pharmacologically versatile nitrogen-containing heterocycle,
has gained more attention from medicinal chemists in the design and synthesis of novel …

This research presents the design and synthesis of a novel series of phthalazine derivatives
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …

Novel series of benzoxazoles 4a‐f‐16 were designed, synthesized, and evaluated for
anticancer activity against HepG2, HCT‐116, and MCF‐7 cells. HCT‐116 was the most …

Inhibiting VEGFR-2 has been set up as a therapeutic strategy for treatment of cancer. Thus,
nineteen new quinazoline-4 (3H)-one derivatives were designed and synthesized …

Abstract Novel series of 5-benzylidenethiazolidine-2, 4-dione derivatives 4 ac-8 af were
designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and …

Herein, we report the synthesis of a series of new quinazoline sulfonamide conjugates 2–16
and their evaluation as potential anticancer agents via dual targeting of EGFR T790M and …

In view of their DNA intercalation activities as anticancer agents, novel fifteen [1, 2, 4] triazolo
[4, 3-c] quinazoline and bis ([1, 2, 4] triazolo)[4, 3-a: 4′, 3′-c] quinazoline derivatives have …

Herein we report the design and synthesis of a new series of phthalazine derivatives as
Topo II inhibitors and DNA intercalators. The synthesized compounds were in vitro …

Novel series of diazepam bearing sulfonamide moieties 5 af and 7 ac were designed,
synthesized and evaluated for anticancer activity against HepG2, HCT-116 and MCF-7 cell …