[HTML][HTML] Implementing New Approach Methodologies (NAMs) in food safety assessments: Strategic objectives and actions taken by the European Food Safety …
I Cattaneo, MC Astuto, M Binaglia, Y Devos… - Trends in Food Science …, 2023 - Elsevier
Abstract Background New Approach Methodologies (NAMs) comprise in silico and in vitro
methods applied as alternative to animal testing. Even though NAMs are already fully …
methods applied as alternative to animal testing. Even though NAMs are already fully …
Interactions of human drug transporters with chemical additives present in plastics: Potential consequences for toxicokinetics and health
V Tastet, M Le Vée, A Bruyère, O Fardel - Environmental Pollution, 2023 - Elsevier
Human membrane drug transporters are recognized as major actors of pharmacokinetics;
they also handle endogenous compounds, including hormones and metabolites. Chemical …
they also handle endogenous compounds, including hormones and metabolites. Chemical …
Development of a roadmap for action on new approach methodologies in risk assessment
SE Escher, F Partosch, S Konzok… - EFSA Supporting …, 2022 - Wiley Online Library
While whole animal studies have their place in risk assessment of food and feed
components, it is thought that more modern approaches such as human focused new …
components, it is thought that more modern approaches such as human focused new …
Human variability in isoform-specific UDP-glucuronosyltransferases: Markers of acute and chronic exposure, polymorphisms and uncertainty factors
UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of
xenobiotics and differences in their isoform activities result in interindividual kinetic …
xenobiotics and differences in their isoform activities result in interindividual kinetic …
[HTML][HTML] Human variability in glutathione-S-transferase activities, tissue distribution and major polymorphic variants: Meta-analysis and implication for chemical risk …
The input into the QIVIVE and Physiologically-Based kinetic and dynamic models of drug
metabolising enzymes performance and their inter-individual differences significantly …
metabolising enzymes performance and their inter-individual differences significantly …
Model systems and organisms for addressing inter-and intra-species variability in risk assessment
Addressing inter-and intra-species differences in potential hazardous effects of chemicals
remains a long-standing challenge in human health risk assessment that is typically …
remains a long-standing challenge in human health risk assessment that is typically …
Human variability in carboxylesterases and carboxylesterase-related uncertainty factors for chemical risk assessment
Carboxylesterases (CES) are an important class of enzymes involved in the hydrolysis of a
range of chemicals and show large inter-individual variability in vitro. An extensive literature …
range of chemicals and show large inter-individual variability in vitro. An extensive literature …
Risk assessment of chemicals in food and feed: principles, applications and future perspectives
In the modern world, chemicals are ubiquitous, and humans, animals and species in the
environment are exposed to an increasing number, both of anthropogenic and natural …
environment are exposed to an increasing number, both of anthropogenic and natural …
Emerging nitrate contamination in groundwater: Changing phase in a fast-growing state of India
The consumption of nitrate-contaminated groundwater is often associated with potential
health risks, particularly in children. This study aimed to assess the hydrochemistry and …
health risks, particularly in children. This study aimed to assess the hydrochemistry and …
[HTML][HTML] Assessing city-wide pharmaceutical emissions to wastewater via modelling and passive sampling
C Zillien, T Groenveld, O Schut, H Beeltje… - Environment …, 2024 - Elsevier
With increasing numbers of chemicals used in modern society, assessing human and
environmental exposure to them is becoming increasingly difficult. Recent advances in …
environmental exposure to them is becoming increasingly difficult. Recent advances in …