Abstract Background New Approach Methodologies (NAMs) comprise in silico and in vitro
methods applied as alternative to animal testing. Even though NAMs are already fully …

Human membrane drug transporters are recognized as major actors of pharmacokinetics;
they also handle endogenous compounds, including hormones and metabolites. Chemical …

While whole animal studies have their place in risk assessment of food and feed
components, it is thought that more modern approaches such as human focused new …

UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of
xenobiotics and differences in their isoform activities result in interindividual kinetic …

The input into the QIVIVE and Physiologically-Based kinetic and dynamic models of drug
metabolising enzymes performance and their inter-individual differences significantly …

Addressing inter-and intra-species differences in potential hazardous effects of chemicals
remains a long-standing challenge in human health risk assessment that is typically …

Carboxylesterases (CES) are an important class of enzymes involved in the hydrolysis of a
range of chemicals and show large inter-individual variability in vitro. An extensive literature …

In the modern world, chemicals are ubiquitous, and humans, animals and species in the
environment are exposed to an increasing number, both of anthropogenic and natural …

The consumption of nitrate-contaminated groundwater is often associated with potential
health risks, particularly in children. This study aimed to assess the hydrochemistry and …

With increasing numbers of chemicals used in modern society, assessing human and
environmental exposure to them is becoming increasingly difficult. Recent advances in …