[HTML][HTML] Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies
Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
Physiological and unappreciated roles of CaMKII in the heart
J Beckendorf, MMG van den Hoogenhof… - Basic research in …, 2018 - Springer
In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation–
contraction and also excitation–transcription coupling. Its activity can be regulated in …
contraction and also excitation–transcription coupling. Its activity can be regulated in …
The sarcoendoplasmic reticulum calcium ATPase
JO Primeau, GP Armanious, MLE Fisher… - … complexes: structure and …, 2018 - Springer
The calcium pump (aka Ca 2+-ATPase or SERCA) is a membrane transport protein
ubiquitously found in the endoplasmic reticulum (ER) of all eukaryotic cells. As a calcium …
ubiquitously found in the endoplasmic reticulum (ER) of all eukaryotic cells. As a calcium …
Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
[HTML][HTML] Targeting calcium homeostasis in myocardial ischemia/reperfusion injury: an overview of regulatory mechanisms and therapeutic reagents
R Wang, M Wang, S He, G Sun, X Sun - Frontiers in pharmacology, 2020 - frontiersin.org
Calcium homeostasis plays an essential role in maintaining excitation–contraction coupling
(ECC) in cardiomyocytes, including calcium release, recapture, and storage. Disruption of …
(ECC) in cardiomyocytes, including calcium release, recapture, and storage. Disruption of …
An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor
OE Reyes Gaido, N Pavlaki, JM Granger… - Science translational …, 2023 - science.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) hyperactivity causes cardiac
arrhythmias, a major source of morbidity and mortality worldwide. Despite proven benefits of …
arrhythmias, a major source of morbidity and mortality worldwide. Despite proven benefits of …
AKAP18δ anchors and regulates CaMKII activity at phospholamban-SERCA2 and RYR
CR Carlson, JM Aronsen, A Bergan-Dahl… - Circulation …, 2022 - Am Heart Assoc
Background: The sarcoplasmic reticulum (SR) Ca2+-ATPase 2 (SERCA2) mediates Ca2+
reuptake into SR and thereby promotes cardiomyocyte relaxation, whereas the ryanodine …
reuptake into SR and thereby promotes cardiomyocyte relaxation, whereas the ryanodine …
CaMKII signaling in heart diseases: emerging role in diabetic cardiomyopathy
Calcium/calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes and
significantly contributes to cardiac remodeling with increased risk of cardiac arrhythmias …
significantly contributes to cardiac remodeling with increased risk of cardiac arrhythmias …
Skeletal and cardiac muscle calcium transport regulation in health and disease
MA Valentim, AN Brahmbhatt, AR Tupling - Bioscience Reports, 2022 - portlandpress.com
In healthy muscle, the rapid release of calcium ions (Ca2+) with excitation–contraction (EC)
coupling, results in elevations in Ca2+ concentrations which can exceed 10-fold that of …
coupling, results in elevations in Ca2+ concentrations which can exceed 10-fold that of …
Role of posttranslational modifications of proteins in cardiovascular disease
Cardiovascular disease (CVD) has become a leading cause of mortality and morbidity
globally, making it an urgent concern. Although some studies have been performed on CVD …
globally, making it an urgent concern. Although some studies have been performed on CVD …