BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

The function that cumulus cells play during oocyte maturation ie, in keeping the oocyte
under arrest, in participating in the induction of meiotic resumption and in supporting …

It is widely recognized that bi-directional communication exists between the human oocyte
and cumulus cells (CCs) which is essential for the production of competent oocytes. CCs …

In cows, protein synthesis is required for germinal vesicle breakdown (GVBD). This study
examines more closely the need for protein synthesis and the nuclear changes in the bovine …

It is estimated that infertility affects 15–20% of couples and can arise from female or male
reproductive defects. Mouse models have ascribed roles to over 100 genes in the …

Meiotic cell cycle in mammalian oocytes is a dynamic process that involves several stop/go
channels. The cell cycle arrest in oocyte occurs at various stages such as diplotene …

encompassed by follicular cells but not on follicular cell monolayer, unless removal of the
zona allows coupling (Buccione et al., 1987). FSH or estradiol does not seem beneficial …

Mammalian oocytes arrest at prophase of meiosis I at around birth and they remain arrested
at this stage until puberty when the preovulatory surge of luteinizing hormone (LH) causes …

The intracellular levels of cAMP play a critical role in the meiotic arrest of mammalian
oocytes. However, it is debated whether this second messenger is produced endogenously …

It is generally accepted that cyclic nucleotides are key signaling molecules in the control of
oocyte meiotic resumption. Given the role of phosphodiesterases (PDEs) in cyclic nucleotide …