The cellular and molecular mechanisms underlying the formation of distinct central, effector,
and exhausted CD8+ T‐cell memory subsets were first described in the setting of acute and …

Many antigens recognized by autologous T lymphocytes have been identified on human
melanoma. Melanoma patients usually mount a spontaneous T cell response against their …

A promising arsenal of targeted and immunotherapy treatments for metastatic melanoma
has emerged over the last decade. With these therapies, we now face new mechanisms of …

This review discusses peptide epitopes used as antigens in the development of vaccines in
clinical trials as well as future vaccine candidates. It covers peptides used in potential …

Although tumor-specific CD8 T-cell responses often develop in cancer patients, they rarely
result in tumor eradication. We aimed at studying directly the functional efficacy of tumor …

During the last decade, increased understanding of the molecular mechanisms responsible
for immune activation to protect against challenges by tumor cells has revolutionized the …

Over the years, the role of biochemical, immunological, genetic, and other biological aspects
in the pathogenesis of vitiligo has been studied. So far, no convincing model describing the …

Purpose: Cancer vaccines aim to generate and maintain antitumor immune responses. We
designed a phase I/IIa clinical trial to test a vaccine formulation composed of Montanide ISA …

Human cancer vaccines are often prepared with altered “analog” or “heteroclitic” antigens
that have been optimized for HLA class I binding, resulting in enhanced immunogenicity …

Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of
their restrict expression in normal tissues and the capacity to elicit an immune response …