Chromatin remodeling BAF (SWI/SNF) complexes in neural development and disorders

G Sokpor, Y Xie, J Rosenbusch, T Tuoc - Frontiers in molecular …, 2017 - frontiersin.org
The ATP-dependent BRG1/BRM associated factor (BAF) chromatin remodeling complexes
are crucial in regulating gene expression by controlling chromatin dynamics. Over the last …

The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective

B Mossink, M Negwer, D Schubert… - Cellular and Molecular …, 2021 - Springer
Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Specialized subpopulations of deep-layer pyramidal neurons in the neocortex: bridging cellular properties to functional consequences

A Baker, B Kalmbach, M Morishima, J Kim… - Journal of …, 2018 - Soc Neuroscience
Neocortical pyramidal neurons with somata in layers 5 and 6 are among the most visually
striking and enigmatic neurons in the brain. These deep-layer pyramidal neurons (DLPNs) …

A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture

A Llorca, G Ciceri, R Beattie, FK Wong, G Diana… - Elife, 2019 - elifesciences.org
The cerebral cortex contains multiple areas with distinctive cytoarchitectonic patterns, but the
cellular mechanisms underlying the emergence of this diversity remain unclear. Here, we …

Development and plasticity of the corpus callosum

NS De León Reyes, L Bragg-Gonzalo… - Development, 2020 - journals.biologists.com
The corpus callosum (CC) connects the cerebral hemispheres and is the major mammalian
commissural tract. It facilitates bilateral sensory integration and higher cognitive functions …

Chromatin remodeling complex NuRD in neurodevelopment and neurodevelopmental disorders

A Hoffmann, D Spengler - Frontiers in genetics, 2019 - frontiersin.org
The nucleosome remodeling and deacetylase (NuRD) complex presents one of the major
chromatin remodeling complexes in mammalian cells. Here, we discuss current evidence for …

Mislocalisation of TDP‐43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex

MS Dyer, LA Reale, KE Lewis, AK Walker… - Journal of …, 2021 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease pathologically
characterised by mislocalisation of the RNA‐binding protein TAR‐DNA‐binding protein 43 …

A critical period of translational control during brain development at codon resolution

D Harnett, MC Ambrozkiewicz, U Zinnall… - Nature Structural & …, 2022 - nature.com
Translation modulates the timing and amplification of gene expression after transcription.
Brain development requires uniquely complex gene expression patterns, but large-scale …

Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity

NS De León Reyes, S Mederos, I Varela… - Nature …, 2019 - nature.com
Interhemispheric axons of the corpus callosum (CC) facilitate the higher order functions of
the cerebral cortex. According to current views, callosal and non-callosal fates are …

Structural and Functional Aspects of the Neurodevelopmental Gene NR2F1: From Animal Models to Human Pathology

C Tocco, M Bertacchi, M Studer - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
The assembly and maturation of the mammalian brain result from an intricate cascade of
highly coordinated developmental events, such as cell proliferation, migration, and …