Simply adding oxygen during hypothermic machine perfusion to combat the negative effects of ischemia-reperfusion injury: fundamentals and current evidence for …

T Darius, J Nath, M Mourad - Biomedicines, 2021 - mdpi.com
The use of high-risk renal grafts for transplantation requires optimization of pretransplant
preservation and assessment strategies to improve clinical outcomes as well as to decrease …

Current evidence and future perspectives to implement continuous and end-ischemic use of normothermic and oxygenated hypothermic machine perfusion in clinical …

M Foguenne, S MacMillan, P Kron, J Nath… - Journal of clinical …, 2023 - mdpi.com
The use of high-risk renal grafts for transplantation requires the optimization of pretransplant
assessment and preservation reconditioning strategies to decrease the organ discard rate …

Intermittent Surface Oxygenation Results in Similar Mitochondrial Protection and Maintenance of Aerobic Metabolism as Compared to Continuous Oxygenation during …

T Darius, M Vergauwen, L Maistriaux, R Evrard… - Journal of clinical …, 2023 - mdpi.com
Short bubble and subsequent surface oxygenation is an innovative oxygenation technique
and alternative for membrane oxygenation during hypothermic machine perfusion (HMP) …

What is the evidence for oxygenation during kidney preservation for transplantation in 2021? A scoping review

B Mesnard, AE Ogbemudia, G Karam, F Dengu… - World journal of …, 2022 - Springer
Purpose The main objective of static cold storage is to reduce cellular metabolic demands to
extend the period of ischaemia prior to transplantation. Hypothermia does not halt …

Advances in hypothermic and normothermic perfusion in kidney transplantation

TB Smith, ML Nicholson, SA Hosgood - Transplantology, 2021 - mdpi.com
Hypothermic and normothermic machine perfusion in kidney transplantation are purported
to exert a beneficial effect on post-transplant outcomes compared to the traditionally used …

Return of the cold: How hypothermic oxygenated machine perfusion is changing liver transplantation

CWG Risbey, NS Lau, A Niu, WB Zhang… - Transplantation …, 2024 - Elsevier
Abstract Hypothermic Oxygenated machine PErfusion (HOPE) has recently emerged as a
preservation technique which can reduce ischemic injury and improve clinical outcomes …

[PDF][PDF] First kidneys transplanted in man after brief bubble and subsequent surface oxygenation as alternative for membrane oxygenation during hypothermic machine …

T Darius, A Devresse, A Buemi, N Kanaan… - Artif …, 2022 - dial.uclouvain.be
Background: Active oxygen during hypothermic machine perfusion has the potential to
improve mitochondrial preservation and subsequently decrease the harmful effects of …

Current Insights into the Metabolome during Hypothermic Kidney Perfusion—A Scoping Review

L Verstraeten, R Den Abt, B Ghesquière… - Journal of Clinical …, 2023 - mdpi.com
This scoping review summarizes what is known about kidney metabolism during
hypothermic perfusion preservation. Papers studying kidney metabolism during hypothermic …

Improving organ preservation: the trick is to keep (cells) breathing

I Jochmans - Transplantation, 2022 - journals.lww.com
A paradigm shift from “one-size-fits-all” cold storage toward preservation tailored to the
needs of a specific organ is essential for the transplantation field to continue to grow …

Hypothermic Organ Perfusion in the 2020's: Mixing the Benefits of Low Temperatures and Dynamic Flow Outside The Body

D Cherkashina, O Petrenko, B Fuller - CryoLetters, 2022 - ingentaconnect.com
The cold chain supply of donor organs for transplantation has been an integral part of the
delivery of transplant clinical services over the past five decades. Within the technologies …