Tumor-on-a-chip: from bioinspired design to biomedical application
X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …
cancer biology and develop anticancer therapies. The main challenges in cancer research …
The plasminogen–activator plasmin system in physiological and pathophysiological angiogenesis
Angiogenesis is a process associated with the migration and proliferation of endothelial
cells (EC) to form new blood vessels. It is involved in various physiological and …
cells (EC) to form new blood vessels. It is involved in various physiological and …
Heterogeneous microenvironmental stiffness regulates pro-metastatic functions of breast cancer cells
Besides molecular and phenotypic variations observed in cancer cells, intratumoral
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …
A 3D bioprinted in vitro model of neuroblastoma recapitulates dynamic tumor‐endothelial cell interactions contributing to solid tumor aggressive behavior
Neuroblastoma (NB) is the most common extracranial tumor in children resulting in
substantial morbidity and mortality. A deeper understanding of the NB tumor …
substantial morbidity and mortality. A deeper understanding of the NB tumor …
Cancer-on-a-chip: models for studying metastasis
Simple Summary Microfluidic-based cancer-on-a-chip models are powerful tools to study the
tumor microenvironment (TME). Two-dimensional cell culture cannot recapitulate TME. In …
tumor microenvironment (TME). Two-dimensional cell culture cannot recapitulate TME. In …
Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation
Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals
generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for …
generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for …
A bioengineered lymphatic vessel model for studying lymphatic endothelial cell‐cell junction and barrier function
Abstract Objective Lymphatic vessels (LVs) maintain fluid homeostasis by draining interstitial
fluid. A failure in lymphatic drainage triggers lymphatic diseases such as lymphedema …
fluid. A failure in lymphatic drainage triggers lymphatic diseases such as lymphedema …
The variety of 3D breast cancer models for the study of tumor physiology and drug screening
E Fröhlich - International Journal of Molecular Sciences, 2023 - mdpi.com
Breast cancer is the most common cancer in women and responsible for multiple deaths
worldwide. 3D cancer models enable a better representation of tumor physiology than the …
worldwide. 3D cancer models enable a better representation of tumor physiology than the …
[HTML][HTML] Microfluidic platforms in diagnostic of ovarian cancer
FD Moghaddam, D Dadgar, Y Esmaeili… - Environmental …, 2023 - Elsevier
The most important reason for death from ovarian cancer is the late diagnosis of this
disease. The standard treatment of ovarian cancer includes surgery and chemotherapy …
disease. The standard treatment of ovarian cancer includes surgery and chemotherapy …
Recent advances in spheroid-based microfluidic models to mimic the tumour microenvironment
Three-dimensional (3D) multicellular spheroid models can recapitulate the human tumour
microenvironment with more accuracy than conventional cell culture models, as they include …
microenvironment with more accuracy than conventional cell culture models, as they include …