Visualization of dynamic functional and molecular events in an unperturbed in vivo
environment is essential for understanding the complex biology of living organisms and of …

Optoacoustic (photoacoustic) imaging offers unique opportunities for visualizing biological
function in vivo by achieving high-resolution images of optical contrast much deeper than …

Photoacoustic (PA) computed tomography (PACT) benefits from genetically encoded probes
with photochromic behavior, which dramatically increase detection sensitivity and specificity …

Highlights•Photoacoustic tomography is capable of molecular imaging with high spatial
resolution and deep penetration depth.•Recent advances in PAT system have made …

Genetically encoded contrast in photoacoustic imaging (PAI) is complementary to the
intrinsic contrast provided by endogenous absorbing chromophores such as hemoglobin …

High transparency, low light-scattering, and low autofluorescence of mammalian tissues in
the near-infrared (NIR) spectral range (~ 650–900 nm) open a possibility for in vivo imaging …

Photoacoustic imaging has been shown to provide high-resolution images of genetically
labelled cells at depths that are inaccessible to optical microscopy. While the detection of …

We introduce two photochromic proteins for cell-specific in vivo optoacoustic (OA) imaging
with signal unmixing in the temporal domain. We show highly sensitive, multiplexed …

Photo-or optoacoustics (OA) imaging is increasingly being used as a non-invasive imaging
method that can simultaneously reveal structure and function in deep tissue. However, the …

In fluorophores, the excited state lifetime can be modulated using pump-probe excitation. By
generating photoacoustic (PA) signals using simultaneous and time-delayed pump and …