Oocyte quality is a key factor influencing IVF success. The oocyte and surrounding cumulus
cells, known collectively as the cumulus oocyte complex (COC), communicate bi …

A major challenge in ART is to select high-quality oocytes and embryos. The metabolism of
oocytes and embryos has long been linked to their viability, suggesting the potential utility of …

Embryo quality is a crucial factor affecting live birth outcomes. However, an accurate
diagnostic for embryo quality remains elusive in the in vitro fertilization clinic. Determining …

Islets prepared for transplantation into type 1 diabetes patients are exposed to
compromising intrinsic and extrinsic factors that contribute to early graft failure, necessitating …

Over the past 4 decades our ability to maintain a viable human embryo in vitro has improved
dramatically, leading to higher implantation rates. This has led to a notable shift to single …

STUDY QUESTION Can non-invasive metabolic imaging via fluorescence lifetime imaging
microscopy (FLIM) detect variations in metabolic profiles between discarded human …

Increasing age has a major detrimental impact on female fertility, which, with an ageing
population, has major sociological implications. This impact is primarily mediated through …

Oocyte developmental potential is intimately linked to metabolism. Existing approaches to
measure metabolism in the cumulus oocyte complex (COC) do not provide information on …

Only 30% of embryos from in vitro fertilized oocytes successfully implant and develop to
term, leading to repeated transfer cycles. To reduce time-to-pregnancy and stress for …

Hyperspectral and multispectral imaging of cell and tissue autofluorescence employs
fluorescence imaging, without exogenous fluorophores, across multiple excitation/emission …