5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Alzheimer's disease (AD) is one of the most frequent causes of death and disability
worldwide and has a significant clinical and socioeconomic impact. In the search for novel …

Introduction This study explored the efficacy and safety of a serotonin‐6 receptor antagonist,
masupirdine, as adjunct treatment in patients with moderate Alzheimer's disease (AD) …

Hypertension is one of the major life-threatening complications of obesity. Recently adipose
multipotent mesenchymal stromal cells (MSCs) were implicated to the pathogenesis of …

Summary Serotonin receptor 6 (5-HT 6 R), a typical G protein-coupled receptor (GPCR)
mainly expressed in the neurogenic area with constitutive activity, is of particular interest as …

The 5-HT6 receptors are potent therapeutic targets for psychiatric and neurological diseases
(schizophrenia, Alzheimer's disease, etc.). However, with lack of specific …

Research in Alzheimer's disease is going through a big turnaround. New palliative therapies
are being reconsidered for the effective management of disease because of setbacks in the …

Abstract Serotonin (5-hydroxytryptamine, 5-HT) is one of the extracellular messengers
capable of activating the largest number of receptors (17 receptors belonging to seven …

The work describes a discovery of new chemical family of potent ligands for the 5-HT 6
serotonin receptors. During the search for new histamine H 4 receptor antagonists among 1 …

While most therapeutic research on G-protein-coupled receptors (GPCRs) focuses on
receptor activation by (endogenous) agonists, significant therapeutic potential exists through …