RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene
expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act …

Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …

Circular RNAs have been identified as naturally occurring RNAs that are highly represented
in the eukaryotic transcriptome. Although a large number of circRNAs have been reported …

Background Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin
protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs …

Circular RNAs (circRNAs) are a class of non-coding RNAs (ncRNAs) that are involved in
transcriptional and posttranscriptional gene expression regulation. The development of …

A new type of RNAs was identified from genes traditionally thought to express messenger or
linear ncRNA (noncoding RNA) only. They were subsequently named as circRNAs (circular …

Circular RNAs (circRNAs), a kind of non-coding RNAs, have shown large capabilities in
gene regulation. However, the mechanisms underlying circRNAs remain largely unknown …

CircRNAs are a class of endogenous RNA that regulates gene expression at the post-
transcriptional or transcriptionallevel through interacting with other molecules or microRNAs …