Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, posing significant
challenges in terms of early prevention, clinical diagnosis, and treatment. Consequently, it …

Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical
manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal …

Sepsis-associated encephalopathy (SAE) is one of the common serious complications in
sepsis, and the pathogenesis of SAE remains unclear. Sirtuin 1 (SIRT1) has been reported …

Ethnopharmacological relevance Paeoniflorin (PF) was found to exhibit renal protection
from diabetic kidney disease (DKD) in previous trials, but its specific mechanism remains to …

Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is the most
significant microvascular complication of diabetes and poses a severe public health concern …

Diabetic kidney disease (DKD), one of the most severe complications of diabetes mellitus
(DM), has received considerable attention owing to its increasing prevalence and …

Introduction Matrine (MT), an ingredient extracted from the Chinese herb Sophora
flavescens, can result in nephrotoxicity because of long-term exposure. However, the …

Autophagy is well-known as an internal catabolic process that is evolutionarily conserved
and performs the key biological function in maintaining cellular homeostasis. It is tightly …

Diabetic nephropathy (DN) is a serious complication of diabetes that causes glomerular
sclerosis and end-stage renal disease, leading to ascending morbidity and mortality in …

Sirtuins are a family of NAD+ III-dependent histone deacetylases that consists of seven
family members, Sirt1-Sirt7, which regulate various signalling pathways and are involved in …