Sex-related differences in the extent of myocardial fibrosis in patients with aortic valve stenosis

L Tastet, J Kwiecinski, P Pibarot, R Capoulade… - Cardiovascular …, 2020 - jacc.org
Objectives The aim of this study was to assess the effect of sex on myocardial fibrosis as
assessed by using cardiac magnetic resonance (CMR) imaging in aortic stenosis (AS) …

Assessment of myocardial fibrosis with T1 mapping MRI

RJ Everett, CG Stirrat, SIR Semple, DE Newby… - Clinical radiology, 2016 - Elsevier
Myocardial fibrosis can arise from a range of pathological processes and its presence
correlates with adverse clinical outcomes. Cardiac magnetic resonance (CMR) can provide …

Matricellular protein CCN5 reverses established cardiac fibrosis

D Jeong, MA Lee, Y Li, DK Yang, C Kho, JG Oh… - Journal of the American …, 2016 - jacc.org
Background: Cardiac fibrosis (CF) is associated with increased ventricular stiffness and
diastolic dysfunction and is an independent predictor of long-term clinical outcomes of …

Type 2 diabetes mellitus and exercise impairment

JEB Reusch, M Bridenstine… - Reviews in Endocrine and …, 2013 - Springer
Limitations in physical fitness, a consistent finding in individuals with both type I and type 2
diabetes mellitus, correlate strongly with cardiovascular and all-cause mortality. These …

Native T1 and ECV of noninfarcted myocardium and outcome in patients with coronary artery disease

VO Puntmann, G Carr-White, A Jabbour, CY Yu… - Journal of the American …, 2018 - jacc.org
Background: Coronary artery disease (CAD) remains the major cause of cardiac morbidity
and mortality worldwide, despite the advances in treatment with coronary revascularization …

Prevalence and prognosis of ischaemic and non-ischaemic myocardial fibrosis in older adults

SM Shanbhag, AM Greve, T Aspelund… - European heart …, 2019 - academic.oup.com
Aims Non-ischaemic cardiomyopathies (NICM) can cause heart failure and death. Cardiac
magnetic resonance (CMR) detects myocardial scar/fibrosis associated with myocardial …

The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction

SJ Greene, M Gheorghiade, BA Borlaug… - Journal of the …, 2013 - Am Heart Assoc
Heart failure with preserved ejection fraction (HFpEF) is a growing public health problem
that accounts for approximately half of all prevalent heart failure (HF). 1, 2 Once believed to …

Myocardial ECV fraction assessed by CMR is associated with type of hemodynamic load and arrhythmia in repaired tetralogy of Fallot

CA Chen, SM Dusenbery, AM Valente… - JACC: Cardiovascular …, 2016 - jacc.org
Objectives: The aim of this study was to investigate the extent of diffuse myocardial fibrosis
by measuring left (LV) and right ventricular (RV) extracellular volume fraction (ECV) in …

Myocardial extracellular volume fraction adds prognostic information beyond myocardial replacement fibrosis

EY Yang, MG Ghosn, MA Khan… - Circulation …, 2019 - Am Heart Assoc
Background: Cardiac magnetic resonance techniques permit quantification of the
myocardial extracellular volume fraction (ECV), representing a surrogate marker of reactive …

Therapeutic targets in heart failure: refocusing on the myocardial interstitium

EB Schelbert, GC Fonarow, RO Bonow, J Butler… - Journal of the American …, 2014 - jacc.org
New therapeutic targets, agents, and strategies are needed to prevent and treat heart failure
(HF) after a decade of failed research efforts to improve long-term patient outcomes …