Macrophage polarization refers to the process by which macrophages can produce two
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …

Cardiovascular disease is the leading cause of mortality and morbidity around the globe,
creating a substantial socio-economic burden as a result. Myocardial infarction is a …

The immune response is tailored to the environment in which it takes place. Immune cells
sense and adapt to changes in their surroundings, and it is now appreciated that in addition …

Atherosclerosis, a chronic inflammatory condition primarily affecting large and medium
arteries, is the main cause of cardiovascular diseases. Macrophages are key mediators of …

Defences to pathogens such as SarCoV2 in mammals involves interactions between
immune functions and metabolic pathways to eradicate infection while preventing …

Macrophages are innate immune cells in the organism and can be found in almost tissues
and organs. They are highly plastic and heterogeneous cells and can participate in the …

Mitochondria are major energy-producing organelles that have central roles in cellular
metabolism. They also act as important signalling hubs, and their dynamic regulation in …

Immunoregulatory B cells impede antitumor immunity through unknown features and
mechanisms. We report the existence of leucine-tRNA-synthetase-2 (LARS2)-expressing B …

To elucidate the function of oxidative phosphorylation (OxPhos) during B cell differentiation,
we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the …

Macrophages are major regulators of angiogenesis in response to injury, but the
mechanisms behind their diverse and phenotypically specific functions are still poorly …