To evaluate the accuracy of biomarkers for the early diagnosis of biliary atresia (BA) and
prognostic stratification after Kasai portoenterostomy (KPE). We conducted a systematic …

The extracellular matrix is a highly reactive scaffold formed by a wide array of multifunctional
molecules, encompassing collagens and noncollagenous glycoproteins, proteoglycans …

Liver fibrosis arises from dysregulated wound healing due to persistent inflammatory hepatic
injury. Periostin is a nonstructural extracellular matrix protein that promotes organ fibrosis in …

Background Periostin is a matricellular protein that serves as a ligand for integrins and is
required for tissue remodeling and fibrosis. We investigated the role of periostin in hepatic …

To identify and evaluate differentially expressed plasma proteins in biliary atresia (BA), we
performed plasma proteome profiling using liquid chromatography with tandem mass …

Biomarkers are incorporated ubiquitously into clini-cal practice as surrogate endpoints of
physiologic and pathologic processes that cannot be measured directly. For example, a lipid …

An effective serum biomarker may improve cholangiocarcinoma (CCA) management.
Periostin (PN) has been demonstrated to be associated with aggressive CCA. The current …

Background The leading pathology of biliary atresia (BA) is inflammatory and fibrous
obstruction of extrahepatic bile duct, but the pathogenesis remains unclear. IL13 is a …

Background Biliary atresia (BA) is a severe congenital disorder with progressive obstructive
cholangiopathy in young children. The inflammatory process has been recognized as one of …

Hepatic Fibrosis Scores and Serum Biomarkers in Pediatric Hepatology Page 1 REVIEW
Hepatic Fibrosis Scores and Serum Biomarkers in Pediatric Hepatology Daniel H. Leung, MD*,† …