Stroke is the second leading cause of global death and is characterized by high rates of
mortality and disability. Oxidative stress is accompanied by other pathological processes …

Central nervous system (CNS) maintains a high level of metabolism, which leads to the
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …

Astrocytes are essential in maintaining normal brain functions such as blood-brain barrier
(BBB) homeostasis and synapse formation as the most abundant cell type in the central …

Background Ischemic stroke is one of the major diseases of the cerebral vasculature.
Currently, Ischemic stroke is the leading cause of neurological disability worldwide and has …

Microglial cells are activated in response to different types of injuries or stress in the CNS.
Such activation is necessary to get rid of the injurious agents and restore tissue …

Senolytic treatment has potential therapeutic efficacy for acute ischemic stroke (AIS).
However, the systemic treatment of senolytics may produce off-target side effects and a toxic …

Astrocytes play an important role in physiological, metabolic, and structural functions, and
when impaired, they can be involved in various pathologies including Alzheimer, focal …

Inflammation is extremely important in the development of cerebral ischemia/reperfusion
injury. Pannexin 1 (Panx1) channel has been reported to activate inflammasome in …

The objective of this paper is to review current information regarding astrocytes function after
a stroke in neonatal and adult brain. Based on the current literature, there are some …

Multiple sclerosis (MS) patients are three to six times more likely to develop epilepsy
compared to the rest of the population. Seizures are more common in patients with early …