Endoplasmic reticulum stress: its role in disease and novel prospects for therapy
AH Schönthal - Scientifica, 2012 - Wiley Online Library
The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis,
calcium storage, and protein folding and processing. A number of physiological and …
calcium storage, and protein folding and processing. A number of physiological and …
[HTML][HTML] Tumor necrosis factor in lung cancer: Complex roles in biology and resistance to treatment
Tumor necrosis factor (TNF) and its receptors are widely expressed in non-small cell lung
cancer (NSCLC). TNF has an established role in inflammation and also plays a key role in …
cancer (NSCLC). TNF has an established role in inflammation and also plays a key role in …
Drug combination approach to overcome resistance to EGFR tyrosine kinase inhibitors in lung cancer
The discovery of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) has
led to unprecedented clinical response in a subset of lung cancer patients carrying the …
led to unprecedented clinical response in a subset of lung cancer patients carrying the …
[PDF][PDF] Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer
NE Bhola, JR Grandis - Front Biosci, 2008 - article.imrpress.com
[Frontiers in Bioscience 13, 1857-1865, January 1, 2008] 1857 Crosstalk between G-protein-coupled
receptors and Epidermal growt Page 1 [Frontiers in Bioscience 13, 1857-1865, January 1 …
receptors and Epidermal growt Page 1 [Frontiers in Bioscience 13, 1857-1865, January 1 …
Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment
JM Lee, J Yanagawa, KA Peebles, S Sharma… - Critical reviews in …, 2008 - Elsevier
Lung carcinogenesis is a complex process involving the acquisition of genetic mutations that
confer cancer development and the malignant phenotype, and is critically linked to …
confer cancer development and the malignant phenotype, and is critically linked to …
[HTML][HTML] Targeting cancer-related inflammation with non-steroidal anti-inflammatory drugs: Perspectives in pharmacogenomics
H Lai, Y Liu, J Wu, J Cai, H Jie, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Inflammatory processes are essential for innate immunity and contribute to carcinogenesis
in various malignancies, such as colorectal cancer, esophageal cancer and lung cancer …
in various malignancies, such as colorectal cancer, esophageal cancer and lung cancer …
Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs
AH Schönthal, TC Chen, FM Hofman… - Expert opinion on …, 2008 - Taylor & Francis
Celecoxib is an NSAID that was developed as a selective inhibitor of COX-2 and approved
by the FDA for the treatment of various forms of arthritis and the management of acute or …
by the FDA for the treatment of various forms of arthritis and the management of acute or …
COX‐2 inhibitors arrest prostate cancer cell cycle progression by down‐regulation of kinetochore/centromere proteins
J Bieniek, C Childress, MD Swatski, W Yang - The Prostate, 2014 - Wiley Online Library
BACKGROUND Previous studies have shown that COX‐2 inhibitors inhibit cancer cell
proliferation. However, the molecular mechanism remains elusive. METHODS Prostate …
proliferation. However, the molecular mechanism remains elusive. METHODS Prostate …
Targeted therapies for non–small cell lung cancer: an evolving landscape
SK Pal, RA Figlin, K Reckamp - Molecular cancer therapeutics, 2010 - AACR
Over the past decade, a multitude of targeted agents have been explored in the treatment of
advanced non–small cell lung cancer (NSCLC). Thus far, two broad classes of agents have …
advanced non–small cell lung cancer (NSCLC). Thus far, two broad classes of agents have …
Selective Cox-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling
Z Wang, Z Fan, H Jiang, J Qu - Carcinogenesis, 2013 - academic.oup.com
Increasing evidence has suggested that high expression level of cyclooxygenase-2 (Cox-2)
is associated with the malignancies of non–small cell lung cancer (NSCLC), leading to a …
is associated with the malignancies of non–small cell lung cancer (NSCLC), leading to a …