Reactive oxygen species scavenging nanomedicine for the treatment of ischemic heart disease

Z Zhang, R Dalan, Z Hu, JW Wang… - Advanced …, 2022 - Wiley Online Library
Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

[HTML][HTML] The anti-inflammatory and antioxidant properties of n-3 PUFAs: Their role in cardiovascular protection

F Oppedisano, R Macrì, M Gliozzi, V Musolino… - Biomedicines, 2020 - mdpi.com
Polyunsaturated fatty acids (n-3 PUFAs) are long-chain polyunsaturated fatty acids with 18,
20 or 22 carbon atoms, which have been found able to counteract cardiovascular diseases …

[HTML][HTML] Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

TJ Park, JH Park, GS Lee, JY Lee, JH Shin… - Cell death & …, 2019 - nature.com
Ischaemic heart disease (IHD) is the leading cause of death worldwide. Although myocardial
cell death plays a significant role in myocardial infarction (MI), its underlying mechanism …

[HTML][HTML] Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications

Y Qin, Y Qiao, D Wang, C Tang, G Yan - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Ferroptosis is a type of regulated cell death driven by iron dependent accumulation of
cellular reactive oxygen species (ROS) when glutathione (GSH)-dependent lipid …

The mitochondrial permeability transition pore: an evolving concept critical for cell life and death

G Morciano, N Naumova, P Koprowski… - Biological …, 2021 - Wiley Online Library
In this review, we summarize current knowledge of perhaps one of the most intriguing
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …

[HTML][HTML] Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management

J He, D Liu, L Zhao, D Zhou… - Experimental and …, 2022 - spandidos-publications.com
Myocardial infarction is one of the primary causes of mortality in patients with coronary heart
disease worldwide. Early treatment of acute myocardial infarction restores blood supply of …

Heat shock proteins in oxidative stress and ischemia/reperfusion injury and benefits from physical exercises: a review to the current knowledge

J Szyller, I Bil-Lula - Oxidative Medicine and Cellular Longevity, 2021 - Wiley Online Library
Heat shock proteins (HSPs) are molecular chaperones produced in response to oxidative
stress (OS). These proteins are involved in the folding of newly synthesized proteins and …

[HTML][HTML] Therapeutic potential of quercetin to alleviate endothelial dysfunction in age-related cardiovascular diseases

O Dagher, P Mury, N Thorin-Trescases… - Frontiers in …, 2021 - frontiersin.org
The vascular endothelium occupies a catalog of functions that contribute to the homeostasis
of the cardiovascular system. It is a physically active barrier between circulating blood and …

Natural allies for heart health: Nrf2 Activation and cardiovascular disease management

SU Khan, SU Khan, M Suleman, MU Khan… - Current Problems in …, 2024 - Elsevier
The term “cardiovascular diseases”(CVD) refers to various ailments that affect the heart and
blood vessels, including myocardial ischemia, congenital heart defects, heart failure …

[HTML][HTML] Research progress on the role of pyroptosis in myocardial ischemia-reperfusion injury

Y Liu, J Zhang, D Zhang, P Yu, J Zhang, S Yu - Cells, 2022 - mdpi.com
Myocardial ischemia-reperfusion injury (MIRI) results in the aggravation of myocardial injury
caused by rapid recanalization of the ischemic myocardium. In the past few years, there is a …