Natural products for pancreatic cancer treatment: From traditional medicine to modern drug discovery

A Kim, J Ha, J Kim, Y Cho, J Ahn, C Cheon, SH Kim… - Nutrients, 2021 - mdpi.com
Pancreatic cancer, the seventh most lethal cancer around the world, is considered
complicated cancer due to poor prognosis and difficulty in treatment. Despite all the …

Herbals and plants in the treatment of pancreatic cancer: A systematic review of experimental and clinical studies

JK Triantafillidis, E Triantafyllidi, M Sideris, T Pittaras… - Nutrients, 2022 - mdpi.com
Background: Pancreatic cancer represents the most lethal malignancy among all digestive
cancers. Despite the therapeutic advances achieved during recent years, the prognosis of …

Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo

L Gou, GGL Yue, JKM Lee, PT Puno… - Biochemical …, 2023 - Elsevier
Breast cancer is the most commonly diagnosed cancer among women, and its metastasis to
distant organs accounts for the majority of death. Eriocalyxin B (Eri B), an ent-kaurane …

Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii

Q Tan, K Hu, XN Li, XZ Yang, HD Sun, PT Puno - Bioorganic Chemistry, 2023 - Elsevier
Twenty new ent-kaurane diterpenoids, wardiisins AT (1–20), along with two previously
undescribed artefactual compounds (21 and 22) and twelve known analogues (23–34) …

5-epi-ent-Kaurane diterpenoids from the aerial parts of Isodon eriocalyx and their anti-atherosclerotic potential

L Mu, T Li, PL Wu, LQ Cai, SY Li, ZY Wang, YY Liu… - Phytochemistry, 2023 - Elsevier
The phytochemical investigation of the EtOAc extract from the aerial parts of Isodon eriocalyx
afforded seventeen diterpenoids, including eight undescribed compounds. Eriocalyxins H …

A pharmacognostic approach for mitigating pancreatic cancer: emphasis on herbal extracts and phytoconstituents

S Gupta, A Kumar, KK Tejavath - Future Journal of Pharmaceutical …, 2021 - Springer
Background Pancreatic cancer is studied as one of the most lethal cancers with currently no
control of its lethality, mainly due to its late diagnosis and lack of foolproof treatment …

Maoeriocalysins A–D, four novel ent-kaurane diterpenoids from Isodon eriocalyx and their structure determination utilizing quantum chemical calculation in …

Q Yang, K Hu, BC Yan, M Liu, XN Li, HD Sun… - Organic Chemistry …, 2019 - pubs.rsc.org
Maoeriocalysin A (1), a novel rearranged ent-kaurane diterpenoid with an unprecedented 4,
5-seco-3, 5-cyclo-7, 20-epoxy-ent-kaurane scaffold, together with three rare 9, 10-seco-7, 20 …

Anticancer hybrid combinations: mechanisms of action, implications and future perspectives

EM Domínguez-Martín, AM Díaz-Lanza… - Current …, 2018 - ingentaconnect.com
The exponential growth of cancer cases worldwide together with recent advances
concerning the pathophysiological mechanisms of the disease at the molecular level led to a …

Eriocalyxin B biological activity: a review on its mechanism of action

A Riaz, B Saleem, G Hussain, I Sarfraz… - Natural Product …, 2019 - journals.sagepub.com
Natural products, a rich source of bioactive chemical compounds, have served humans as a
safer drug of choice since times. Eriocalyxin B, an ent-Kaurene diterpenoid, has been …

Eriocalyxin B inhibits Adipogenesis in 3T3-L1 adipocytes by cell cycle arrest

RF Mu, YF Niu, Q Wang, HM Zhou, J Hu… - Natural Products and …, 2020 - Springer
Eriocalyxin B, an ent-Kaurene diterpenoid extracted from a traditional Chinese herb Isodon
eriocalyx, has been shown to possess multifunctional activities such as anti-cancer and anti …