Whole-genome sequencing (WGS) of pathogens is becoming increasingly important not
only for basic research but also for clinical science and practice. In virology, WGS is …

This manuscript reviews the reasons why Integrase inhibitors should now routinely
constitute a part of first line antiretroviral therapy for the treatment of HIV disease. The use of …

Background Implementation of ultrasensitive HIV drug resistance tests for routine clinical
use is hampered by uncertainty about the clinical relevance of drug-resistant minority …

Human immunodeficiency virus type 1 (HIV-1) drug resistance genotyping is recommended
to help in the selection of antiretroviral therapy and to prevent virologic failure. There are …

Human cytomegalovirus (HCMV) represents a major threat to human health, contributing to
both birth defects in neonates as well as organ transplant failure and opportunistic infections …

Background Integrase strand transfer inhibitors (INSTIs) are recommended by international
guidelines as first-line therapy in antiretroviral-naive and-experienced HIV-1-infected …

ABSTRACT HIV drug resistance genotyping is a critical tool in the clinical management of
HIV infections. Although resistance genotyping has traditionally been conducted using …

Next-generation sequencing (NGS) offers a powerful opportunity to identify low-abundance,
intra-host viral sequence variants, yet the focus of many bioinformatic tools on consensus …

Objectives The main objective of this analysis was to evaluate the impact of pre‐existing
drug resistance by next‐generation sequencing (NGS) on the risk of treatment failure (TF) of …

The present study compares the performances of an in‐house sequencing protocol
developed on MiSeq, the Sanger method, and the 454 GS‐FLX for detecting and quantifying …