Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets
S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018 - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …
Pregabalin: its pharmacology and use in pain management
NM Gajraj - Anesthesia & Analgesia, 2007 - journals.lww.com
Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory
neurotransmitter γ-aminobutyric acid. It is an α 2-δ (α 2-δ) ligand that has analgesic …
neurotransmitter γ-aminobutyric acid. It is an α 2-δ (α 2-δ) ligand that has analgesic …
Pregabalin in neuropathic pain: evidences and possible mechanisms
V Verma, N Singh, A Singh Jaggi - Current neuropharmacology, 2014 - ingentaconnect.com
Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-
2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the …
2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the …
Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy
A Agarwal, S Gautam, D Gupta… - British journal of …, 2008 - academic.oup.com
Background Postoperative pain is the dominating complaint and the primary reason for
prolonged convalescence after laparoscopic cholecystectomy. We have evaluated the …
prolonged convalescence after laparoscopic cholecystectomy. We have evaluated the …
A comparative efficacy of amitriptyline, gabapentin, and pregabalin in neuropathic cancer pain: a prospective randomized double-blind placebo-controlled study
S Mishra, S Bhatnagar, GN Goyal… - American Journal of …, 2012 - journals.sagepub.com
Neuropathic pain is difficult to diagnose and difficult to treat with certainty. So the aim of the
study was to evaluate comparative clinical efficacy of pregabaline with amitriptyline and …
study was to evaluate comparative clinical efficacy of pregabaline with amitriptyline and …
Treating pain in diabetic neuropathy: current and developmental drugs
There is a high prevalence of painful diabetic polyneuropathy (pDPN) with around one-third
of all patients with diabetes suffering from pDPN. pDPN has debilitating consequences, with …
of all patients with diabetes suffering from pDPN. pDPN has debilitating consequences, with …
Chemokines: integrators of pain and inflammation
Chronic (neuropathic) pain is one of the most widespread and intractable of human
complaints, as well as being one of the most difficult syndromes to treat successfully with …
complaints, as well as being one of the most difficult syndromes to treat successfully with …
[HTML][HTML] Efficacy and safety of pregabalin 600 mg/d for treating painful diabetic peripheral neuropathy: a double-blind placebo-controlled trial
JC Arezzo, J Rosenstock, L LaMoreaux, L Pauer - BMC neurology, 2008 - Springer
Background Recent consensus guidelines recommend pregabalin as a first-tier treatment for
painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of pregabalin 600 …
painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of pregabalin 600 …
A randomized, placebo-controlled trial of preoperative oral pregabalin for postoperative pain relief after minor gynecological surgery
BACKGROUND: Although pregabalin shows efficacy against neuropathic pain, very limited
evidence supports postoperative analgesic efficacy. Our study objective was to investigate …
evidence supports postoperative analgesic efficacy. Our study objective was to investigate …
The analgesic efficacy of celecoxib, pregabalin, and their combination for spinal fusion surgery: retracted
SS Reuben, A Buvanendran, JS Kroin… - Anesthesia & …, 2006 - journals.lww.com
RETRACTED ARTICLE Page 1 RETRACTED ARTICLE Pain Medicine Section Editor: Spencer
S. Liu The Analgesic Efficacy of Celecoxib, Pregabalin, and Their Combination for Spinal Fusion …
S. Liu The Analgesic Efficacy of Celecoxib, Pregabalin, and Their Combination for Spinal Fusion …