Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018 - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Pregabalin: its pharmacology and use in pain management

NM Gajraj - Anesthesia & Analgesia, 2007 - journals.lww.com
Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory
neurotransmitter γ-aminobutyric acid. It is an α 2-δ (α 2-δ) ligand that has analgesic …

Pregabalin in neuropathic pain: evidences and possible mechanisms

V Verma, N Singh, A Singh Jaggi - Current neuropharmacology, 2014 - ingentaconnect.com
Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-
2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the …

Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy

A Agarwal, S Gautam, D Gupta… - British journal of …, 2008 - academic.oup.com
Background Postoperative pain is the dominating complaint and the primary reason for
prolonged convalescence after laparoscopic cholecystectomy. We have evaluated the …

A comparative efficacy of amitriptyline, gabapentin, and pregabalin in neuropathic cancer pain: a prospective randomized double-blind placebo-controlled study

S Mishra, S Bhatnagar, GN Goyal… - American Journal of …, 2012 - journals.sagepub.com
Neuropathic pain is difficult to diagnose and difficult to treat with certainty. So the aim of the
study was to evaluate comparative clinical efficacy of pregabaline with amitriptyline and …

Treating pain in diabetic neuropathy: current and developmental drugs

U Alam, G Sloan, S Tesfaye - Drugs, 2020 - Springer
There is a high prevalence of painful diabetic polyneuropathy (pDPN) with around one-third
of all patients with diabetes suffering from pDPN. pDPN has debilitating consequences, with …

Chemokines: integrators of pain and inflammation

FA White, SK Bhangoo, RJ Miller - Nature reviews Drug discovery, 2005 - nature.com
Chronic (neuropathic) pain is one of the most widespread and intractable of human
complaints, as well as being one of the most difficult syndromes to treat successfully with …

[HTML][HTML] Efficacy and safety of pregabalin 600 mg/d for treating painful diabetic peripheral neuropathy: a double-blind placebo-controlled trial

JC Arezzo, J Rosenstock, L LaMoreaux, L Pauer - BMC neurology, 2008 - Springer
Background Recent consensus guidelines recommend pregabalin as a first-tier treatment for
painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of pregabalin 600 …

A randomized, placebo-controlled trial of preoperative oral pregabalin for postoperative pain relief after minor gynecological surgery

MJ Paech, R Goy, S Chua, K Scott… - Anesthesia & …, 2007 - journals.lww.com
BACKGROUND: Although pregabalin shows efficacy against neuropathic pain, very limited
evidence supports postoperative analgesic efficacy. Our study objective was to investigate …

The analgesic efficacy of celecoxib, pregabalin, and their combination for spinal fusion surgery: retracted

SS Reuben, A Buvanendran, JS Kroin… - Anesthesia & …, 2006 - journals.lww.com
RETRACTED ARTICLE Page 1 RETRACTED ARTICLE Pain Medicine Section Editor: Spencer
S. Liu The Analgesic Efficacy of Celecoxib, Pregabalin, and Their Combination for Spinal Fusion …