Depression in patients with Parkinson's disease: current understanding of its neurobiology and implications for treatment

S Prange, H Klinger, C Laurencin, T Danaila… - Drugs & Aging, 2022 - Springer
Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

Depression in Parkinson disease—epidemiology, mechanisms and management

D Aarsland, S Påhlhagen, CG Ballard, U Ehrt… - Nature Reviews …, 2012 - nature.com
Depression occurs in around 35% of patients with Parkinson disease (PD) and is often
persistent. Symptoms of depression can be evident in individuals at the time of diagnosis …

Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms

VD Felice, EM Quigley, AM Sullivan… - Parkinsonism & related …, 2016 - Elsevier
Parkinson's disease is the second most common neurodegenerative disorder, affecting 1–
2% of the population over 65 years of age. The primary neuropathology is the loss of …

Pain in parkinson s disease: a cross-sectional study of its prevalence, types, and relationship to depression and quality of life

P Valkovic, M Minar, H Singliarova, J Harsany… - PLoS …, 2015 - journals.plos.org
Pain is an important and distressing symptom in Parkinson's disease (PD). Our aim was to
determine the prevalence of pain, its various types and characteristics, as well as its impact …

Pain in Parkinson's disease

AD Ha, J Jankovic - Movement Disorders, 2012 - Wiley Online Library
Pain and other nonmotor symptoms in PD are increasingly recognized as a major cause of
reduced health‐related quality of life. Pain in PD may be categorized into a number of …

Neurotransmission in Parkinson's disease: beyond dopamine

P Barone - European journal of neurology, 2010 - Wiley Online Library
Parkinson's disease (PD) is most frequently associated with characteristic motor symptoms
that are known to arise with degeneration of dopaminergic neurons. However, patients with …

[HTML][HTML] Pain in Parkinson disease: a review of the literature

A Fil, R Cano-de-la-Cuerda, E Muñoz-Hellín… - Parkinsonism & related …, 2013 - Elsevier
Parkinson's disease (PD) is a degenerative neurological disease presenting with motor and
non-motor signs and symptoms. Approximately 30–50% of the patients experience pain …

Chronic pain and pain processing in Parkinson's disease

PJ Blanchet, C Brefel-Courbon - Progress in Neuro-Psychopharmacology …, 2018 - Elsevier
Pain is experienced by the vast majority of patients living with Parkinson's disease. It is most
often of nociceptive origin, but may also be ascribed to neuropathic (radicular or central) or …

Lewy pathology and neurodegeneration in premotor Parkinson's disease

K Del Tredici, H Braak - Movement disorders, 2012 - Wiley Online Library
The foremost motor manifestations of Parkinson's disease are resting tremor, cogwheel
rigidity, hypokinesia/bradykinesia, and postural instability. Epidemiological and clinical data …

The patients' perception of prodromal symptoms before the initial diagnosis of Parkinson's disease

A Gaenslen, I Swid, I Liepelt‐Scarfone… - Movement …, 2011 - Wiley Online Library
Background: Before the occurrence of motor symptoms permits the clinical diagnosis of
Parkinson's disease (PD), about or even more than 50% of the dopaminergic neurons of the …