Chagas disease (CD) is a tropical neglected illness, affecting mainly populations of low
socioeconomic status in Latin America. An estimated 6 to 8 million people worldwide are …

Protozoan parasites interact with a wide variety of organisms ranging from bacteria to
humans, representing one of the most common causes of parasitic diseases and an …

Background The treatment of leishmaniasis with pentavalent antimonials is problematic
because of their toxicity. Investigations of potentially active molecules are important to …

Background Leishmaniasis is a parasitic disease associated with extensive mortality and
morbidity. The treatment for leishmaniasis is currently based on pentavalent antimonials and …

Over the past years, natural products have been explored in order to find biological active
substances to treat various diseases. Regarding their potential action against parasites such …

Alzheimer's disease (AD) is the most common form of dementia and has no cure.
Therapeutic strategies focusing on the reduction of oxidative stress, modulation of amyloid …

Background Major drawbacks of the available treatment against Chagas disease (American
trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the …

Leishmaniasis is endemic in 98 countries and territories worldwide. The therapies available
for leishmaniasis have serious side effects, thus prompting the search for new therapies. The …

Despite ongoing efforts, the available treatments for Chagas' disease are still unsatisfactory,
especially in the chronic phase of the disease. Our previous study reported the strong …

This work describes the isolation of six metabolites from leaves and branches of Piper
cernuum (Piperaceae):(−)-cubebin (1),(−)-hinokinin (2),(−)-kusunokinin (3), trans …