Docetaxel (Taxotere®) has been one of the most important chemotherapeutic drugs for
cancer treatment since 1996. Although a large number of clinical studies have been …

The use of oral anticancer drugs has increased during the last decade, because of patient
preference, lower costs, proven efficacy, lack of infusion-related inconveniences, and the …

Purpose Standard therapy for advanced ovarian cancer consists of a platinum agent in
combination with a taxane, which has a 5-year survival rate of approximately 45%. The large …

Abstract Cytochrome 450 (CYP450) designates a group of enzymes abundant in smooth
endoplasmic reticulum of hepatocytes and epithelial cells of small intestines. The main …

Simple Summary Overexpression of ABCB1 has been identified in a wide range of multidrug-
resistant cancers. ABCB1 can become upregulated in many ways, and understanding these …

The purpose of this study was to evaluate the affinity of docetaxel for 14 transporter proteins
and assess the functional significance of 17 variants in five genes involved in drug …

The inter-individual differences in cancer susceptibility are somehow correlated with the
genetic differences that are caused by the polymorphisms. These genetic variations in drug …

Purpose: Polymorphisms that are associated with ABCB1 expression and function may be
linked to treatment efficacy and the development of neutropenia and neurotoxicity in patients …

Today's drug therapy regimens rely on the anticipated relation between drug dose, acquired
plasma level and desired effect. However, the capacity of individual patients to absorb and …

Although global clinical trials for lung cancer can enable the development of new agents
efficiently, whether the results of clinical trials performed in one population can be fully …