Clinical value of metagenomic next-generation sequencing using spinal tissue in the rapid diagnosis of spinal tuberculosis

Y Jin, S Hu, J Feng, J Ni - Infection and Drug Resistance, 2023 - Taylor & Francis
Purpose To evaluate the accuracy of metagenomic next-generation sequencing (mNGS) for
rapid diagnosis of spinal tuberculosis using spinal tissue specimens. Methods Medical data …

Development of a Diagnostic Model for Differentiating Tuberculous Spondylitis and Pyogenic Spondylitis With MRI: A Multicenter Retrospective Observational Study

J Wang, Z Li, X Chi, Y Chen, H Wang, X Wang, K Cui… - Spine, 2024 - journals.lww.com
Study Design. Multicenter retrospective observational study. Objective. This study aimed to
distinguish tuberculous spondylitis (TS) from pyogenic spondylitis (PS) using magnetic …

高通量测序文库质量控制技术研究进展

崔梦楠, 郭彦, 武雅蓉, 裴广倩, 崔玉军 - 遗传, 2024 - chinagene.cn
作为生命科学和医学领域中的关键性支撑技术, 高通量测序已得到快速发展并日趋成熟.
该技术工作流程可分为核酸提取, 文库构建, 上机测序, 数据分析等, 其中文库构建是承上启下的 …

Identification of pathogen composition in a Chinese population with iatrogenic and native vertebral osteomyelitis by using mNGS

Q Gao, Q Liu, G Zhang, Y Lu, Y Li, M Tang… - Annals of …, 2024 - Taylor & Francis
Background Early antimicrobial therapy is crucial regarding the prognosis of vertebral
osteomyelitis, but early pathogen diagnosis remains challenging. Objective In this study, we …

Diagnostic Efficacy of Metagenomic Next-Generation Sequencing in Patients with Spinal Infections: A Retrospective Study

H Cheng, H Wu, N Tan, Z Liu, N Wang… - Infection and Drug …, 2023 - Taylor & Francis
Purpose Early diagnosis of spinal infections remains challenging, and emerging
metagenomic next-generation sequencing (mNGS) technology holds promise in addressing …