The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …

The liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering
the body via the gut, the liver appears designed to detect, capture, and clear bacteria …

Aims The objectives of this study were to (1) characterize the epidemiology of liver
metastases at the time of primary cancer diagnosis (synchronous liver metastases),(2) …

Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …

Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

The high rate of failure during drug development is well-known, however recent advances in
tissue engineering and microfabrication have contributed to the development of …

The vLAMPS is a human, biomimetic liver MPS, in which the ECM and cell seeding of the
intermediate layer prior to assembly, simplifies construction of the model and makes the …

This article describes our next generation human Liver Acinus MicroPhysiology System
(LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 …

Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in
treatment over the past several decades have significantly improved the outlook for this …

Lung cancer, renowned for its fast progression and metastatic potency, is rising to become a
leading cause of death globally. It has been long observed that lung cancer is particularly …