Epilepsy is a common neurological disorder characterised by recurrent epileptic seizures. It
affects approximately 0.7% of the worldwide population. Even though many patients …

Date: 18.07. 2021 Epilepsy is a kind of chronic brain disfunction, manifesting as recurrent
seizures which is caused by sudden and excessive discharge of neurons …

Objective: Pharmacoresistant epilepsy represents a significant global health challenge,
necessitating novel therapeutic approaches. Despite advances in antiseizure medications …

The balance between inhibition and excitation is at the basis of the maintenance of stable
and normal brain electrical activity. Experimental results revealed that inhibitory synapses …

Epilepsy affects over 45 million people worldwide and while treatment options exist,
antiepileptic drugs don't work in up to 50% of the cases; furthermore, poorly-treated epilepsy …

The observations of GABAergic interneurons leading the transition into seizure events is
antithetical to the current framework that seizures (“ictogenesis”) manifest from excessive …

Over 30% of patients with Epilepsy exhibit drug-resistance, elucidating the need for novel
anticonvulsant drugs. The cannabis plant has been shown to be beneficial in treating …

Epilepsy is a devastating condition, impacting over 50 million people worldwide.
Understanding and treating this disease remains a challenge because of its heterogeneous …

Altered inhibitory function is an important facet of epileptic pathology. A key concept is that
GABAergic activity can become excitatory, if intraneuronal chloride [Cl-] i rises. It has proved …

We present work in this dissertation on methods to map measured electrode signals from
human subjects into the physiologically relevant parameter space of a mathematical model …