Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal central nervous
system tumor commonly affecting children< 3 years of age. It roughly constitutes 1%–2% of …

Simple Summary Medulloblastoma is the commonest malignant brain tumour of childhood.
Disease relapse following maximal multi-modal therapy including upfront craniospinal …

Purpose Chemotherapy for relapsed medulloblastoma has been inadequate, and most
patients succumb to disease. Methods We retrospectively reviewed nine cases of relapsed …

Atypical teratoid rhabdoid tumor (ATRT) is a rare, highly malignant central nervous system
cancer arising in infants and younger children, historically considered to be homogeneous …

Aim To assess objective response after two cycles of temozolomide and topotecan (TOTEM)
in children with refractory or relapsed miscellaneous extracranial solid and central nervous …

Background This multicenter phase II study investigated temozolomide+ irinotecan (TEMIRI)
treatment in children with relapsed or refractory medulloblastoma. Methods Patients …

Background: Temozolomide shows activity against medulloblastoma, the most common
malignant paediatric brain tumour. Poly (ADP-ribose) polymerase (PARP) inhibitors …

Atypical teratoid/rhabdoid tumor is predominantly a childhood tumor and has only been
rarely reported in adults; therefore, treatment regimens are often extrapolated from the …

Background and purpose Treatment of patients with atypical teratoid/rhabdoid (AT/RT) is
challenging, especially when very young (below the age of three years). Radiotherapy (RT) …

Despite advances in the treatment of brain tumors, the prognosis of children with recurrent
malignant brain tumors remains poor. Etoposide (VP-16), an inhibitor of nuclear enzyme …