Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

The development and immune evasion of cancer stem cells (CSCs) limit the efficacy of
currently available anticancer therapies. Recent studies have shown that epigenetic …

Abstract Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes
stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies …

Dysregulation of various cells in the tumor microenvironment (TME) causes
immunosuppressive functions and aggressive tumor growth. In combination with immune …

Ewing sarcoma (EwS), a type of bone and soft tissue tumor, is mainly driven by the
expression of the fusion protein EWSR1-FLI1. Upon binding to chromatin, EWSR1-FLI1 …

Cobalamin or vitamin B12 (B12) is a cofactor for methionine synthase and methylmalonyl-
CoA mutase, two enzymes implicated in key pathways for cell proliferation: methylation …

Background Lysine-specific demethylase 1 (LSD1) is an essential epigenetic regulator of
hematopoietic differentiation, which can specifically mono-methylate H3K4 (H3K4me1) and …

Lung cancer is a global public health issue, with non-small cell lung cancer (NSCLC)
accounting for 80–85% of cases. With over two million new diagnoses annually …

The trithorax protein ASH2L is essential for organismal and tissue development. As a
subunit of COMPASS/KMT2 complexes, ASH2L is necessary for methylation of histone H3 …

Lysine-specific demethylase 1 (LSD1), a highly sophisticated epigenetic regulator,
orchestrates a range of critical cellular processes, holding promising therapeutic potential for …