CRISPR/Cas9 technology as a potent molecular tool for gene therapy
Clustered regularly interspaced short palindromic repeats/CRISPR‐associated nuclease 9
(CRISPR‐Cas9) is an RNA‐guided gene editing tool which offers several advantageous …
(CRISPR‐Cas9) is an RNA‐guided gene editing tool which offers several advantageous …
Neural stem cells of the subventricular zone as the origin of human glioblastoma stem cells. Therapeutic implications
ER Matarredona, AM Pastor - Frontiers in oncology, 2019 - frontiersin.org
Human glioblastoma is the most aggressive type of primary malignant brain tumors.
Standard treatment includes surgical resection followed by radiation and chemotherapy but …
Standard treatment includes surgical resection followed by radiation and chemotherapy but …
[HTML][HTML] Hallmarks of cancer: The CRISPR generation
C Moses, B Garcia-Bloj, AR Harvey… - European Journal of …, 2018 - Elsevier
The hallmarks of cancer were proposed as a logical framework to guide research efforts that
aim to understand the molecular mechanisms and derive treatments for this highly complex …
aim to understand the molecular mechanisms and derive treatments for this highly complex …
Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity
Large-scale genomic analyses of human cancers have cataloged somatic point mutations
thought to initiate tumor development and sustain cancer growth. However, determining the …
thought to initiate tumor development and sustain cancer growth. However, determining the …
Sox2 is required for tumor development and cancer cell proliferation in osteosarcoma
The stem cell transcription factor Sox2 is highly expressed in many cancers where it is
thought to mark cancer stem cells (CSCs). In osteosarcomas, the most common bone …
thought to mark cancer stem cells (CSCs). In osteosarcomas, the most common bone …
Emerging functional markers for cancer stem cell-based therapies: Understanding signaling networks for targeting metastasis
S Marquardt, M Solanki, A Spitschak, J Vera… - Seminars in cancer …, 2018 - Elsevier
Metastasis is one of the most challenging issues in cancer patient management, and
effective therapies to specifically target disease progression are missing, emphasizing the …
effective therapies to specifically target disease progression are missing, emphasizing the …
[HTML][HTML] Glioblastoma: new therapeutic strategies to address cellular and genomic complexity
X Cai, ME Sughrue - Oncotarget, 2018 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most invasive and devastating primary brain tumor with a median
overall survival rate about 18 months with aggressive multimodality therapy. Its unique …
overall survival rate about 18 months with aggressive multimodality therapy. Its unique …
Emerging role of CRISPR/Cas9 technology for microRNAs editing in cancer research
G Aquino-Jarquin - Cancer research, 2017 - AACR
MicroRNAs (miRNA) are small, noncoding RNA molecules with a master role in the
regulation of important tasks in different critical processes of cancer pathogenesis. Because …
regulation of important tasks in different critical processes of cancer pathogenesis. Because …
Evaluating the transcriptional fidelity of cancer models
Background Cancer researchers use cell lines, patient-derived xenografts, engineered mice,
and tumoroids as models to investigate tumor biology and to identify therapies. The …
and tumoroids as models to investigate tumor biology and to identify therapies. The …
Animal models to study microRNA function
AS Pal, AL Kasinski - Advances in cancer research, 2017 - Elsevier
The discovery of the microRNAs, lin-4 and let-7 as critical mediators of normal development
in Caenorhabditis elegans and their conservation throughout evolution has spearheaded …
in Caenorhabditis elegans and their conservation throughout evolution has spearheaded …