Clustered regularly interspaced short palindromic repeats/CRISPR‐associated nuclease 9
(CRISPR‐Cas9) is an RNA‐guided gene editing tool which offers several advantageous …

Human glioblastoma is the most aggressive type of primary malignant brain tumors.
Standard treatment includes surgical resection followed by radiation and chemotherapy but …

The hallmarks of cancer were proposed as a logical framework to guide research efforts that
aim to understand the molecular mechanisms and derive treatments for this highly complex …

Large-scale genomic analyses of human cancers have cataloged somatic point mutations
thought to initiate tumor development and sustain cancer growth. However, determining the …

The stem cell transcription factor Sox2 is highly expressed in many cancers where it is
thought to mark cancer stem cells (CSCs). In osteosarcomas, the most common bone …

Metastasis is one of the most challenging issues in cancer patient management, and
effective therapies to specifically target disease progression are missing, emphasizing the …

Glioblastoma (GBM) is the most invasive and devastating primary brain tumor with a median
overall survival rate about 18 months with aggressive multimodality therapy. Its unique …

MicroRNAs (miRNA) are small, noncoding RNA molecules with a master role in the
regulation of important tasks in different critical processes of cancer pathogenesis. Because …

Background Cancer researchers use cell lines, patient-derived xenografts, engineered mice,
and tumoroids as models to investigate tumor biology and to identify therapies. The …

The discovery of the microRNAs, lin-4 and let-7 as critical mediators of normal development
in Caenorhabditis elegans and their conservation throughout evolution has spearheaded …