[HTML][HTML] Advances and applications of biomimetic biomaterials for endogenous skin regeneration

M Wang, Y Hong, X Fu, X Sun - Bioactive Materials, 2024 - Elsevier
Endogenous regeneration is becoming an increasingly important strategy for wound healing
as it facilitates skin's own regenerative potential for self-healing, thereby avoiding the risks of …

Spatial transcriptomics reveals heterogeneity of histological subtypes between lepidic and acinar lung adenocarcinoma

L Xie, H Kong, J Yu, M Sun, S Lu… - Clinical and …, 2024 - Wiley Online Library
Background Patients who possess various histological subtypes of early‐stage lung
adenocarcinoma (LUAD) have considerably diverse prognoses. The simultaneous …

Identification and validation of an immune-derived multiple programmed cell death index for predicting clinical outcomes, molecular subtyping, and drug sensitivity in …

C Li, J Hu, X Jiang, H Tan, Y Mao - Clinical and Translational Oncology, 2024 - Springer
Objectives Comprehensive cross-interaction of multiple programmed cell death (PCD)
patterns in the patients with lung adenocarcinoma (LUAD) have not yet been thoroughly …

Comparison of gene mutation profile in different lung adenocarcinoma subtypes by targeted next-generation sequencing

S Zhang, P Dong, Z Pan, Q Chen, J Zhu, Z Mao - Medical Oncology, 2023 - Springer
Background Disease prognosis after resection of lung cancer could be affected by
pathological subtypes. In this study, we investigated the difference of gene variation and …

Integrating IASLC grading and radiomics for predicting postoperative outcomes in stage IA invasive lung adenocarcinoma

Y Chen, J Wu, J You, M Gao, S Lu, C Sun… - Medical …, 2024 - Wiley Online Library
Abstract Background The International Association for the Study of Lung Cancer (IASLC)
Pathology Committee introduced a histologic grading system for invasive lung …

[HTML][HTML] Biophysical model for DNA mutations induced by retroviral genome insertion based on the probability density function of mutation distribution

T Tsuruyama, T Hiratsuka - The European Physical Journal Plus, 2023 - Springer
Research into the biophysical properties of deoxyribonucleic acid (DNA) and the
mechanisms underlying genetic mutations has undergone marked advancements. The …

A cellular and spatial atlas of TP53-associated tissue remodeling in lung adenocarcinoma

W Zhao, B Kepecs, NR Mahadevan, A Segerstolpe… - bioRxiv, 2023 - biorxiv.org
ABSTRACT TP53 is the most frequently mutated gene across many cancers and is
associated with shorter survival in lung adenocarcinoma (LUAD). To define how TP53 …

Patho-transcriptomic analysis of invasive mucinous adenocarcinoma of the lung (IMA): comparison with lung adenocarcinoma with signet ring cell features (SRCC)

WD Stuart, M Ito, IM Fink-Baldauf, T Fukazawa… - bioRxiv, 2024 - biorxiv.org
Background Invasive mucinous adenocarcinoma (IMA) comprises~ 5% of lung
adenocarcinoma. There is no effective therapy for IMA when surgical resection is not …

Spatial transcriptomics: a new frontier in cancer research

S Huang, L Ouyang, J Tang, K Qian, X Chen, Z Xu… - Clinical Cancer …, 2024 - Springer
Tumor research is a fundamental focus of medical science, yet the intrinsic heterogeneity
and complexity of tumors present challenges in understanding their biological mechanisms …

Spatial resolution of transcriptomic plasticity states underpinning lethal morphologies in lung adenocarcinoma

HL Williams, N Poulain, I Powley, S Martinelli, R Bielik… - bioRxiv, 2024 - biorxiv.org
Adenocarcinoma of the lung (LUAD) is a common and highly lethal disease. Clinical grading
of disease strongly predicts recurrence and survival after surgery and is determined by …