While inbred mice have informed most of what we know about the immune system in the
modern era, they have clear limitations with respect to their ability to be informative …

Infection of humans with the nematode worm parasite Anisakis simplex was first described in
the 1960s in association with the consumption of raw or undercooked fish. During the 1990s …

To identify disease-relevant T cell receptors (TCRs) with shared antigen specificity, we
analyzed 778,938 TCRβ chain sequences from 178 non-small cell lung cancer patients …

A large body of evidence suggests the existence of polarized human T cell responses,
reminiscent of Th1 and Th2 subsets described for mouse T cells. Human Th1-like cells …

SLE is a chronic autoimmune disease caused by perturbations of the immune system. The
clinical presentation is heterogeneous, largely because of the multiple genetic and …

Molecular mimicry has been proposed as a pathogenetic mechanism for autoimmune
disease, as well as a probe useful in uncovering its etiologic agents. The hypothesis is …

Human CD4+ T cells, activated by allogeneic monocytes in a primary mixed lymphocyte
reaction in the presence of exogenous interleukin (IL) 10, specifically failed to proliferate …

Systemic lupus erythematosus (SLE), an autoimmune disorder which primarily aVects
women (10: 1 female to male ratio), may aVect virtually any organ. 1 Predominant …

Publisher Summary This chapter provides evidence that indicates a potential role for
superantigens in the pathogenesis of several human diseases. The term “superantigen” was …

The normal function of the nervous system is conditioned by the undisturbed function of the
thyroid gland and its hormones. Comprehensive clinical manifestations, including …