[HTML][HTML] The intracellular signalosome of PD-L1 in cancer cells
Abstract Programmed cell death-1 ligand-1 (PD-L1) overexpression in cancer cells
accelerates tumor progression. PD-L1 possesses two main pro-oncogenic functions. First …
accelerates tumor progression. PD-L1 possesses two main pro-oncogenic functions. First …
[HTML][HTML] Mission possible: advances in MYC therapeutic targeting in cancer
BL Allen-Petersen, RC Sears - BioDrugs, 2019 - Springer
MYC is a master transcriptional regulator that controls almost all cellular processes. Over the
last several decades, researchers have strived to define the context-dependent …
last several decades, researchers have strived to define the context-dependent …
Therapeutic targeting of PP2A
Abstract Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that
regulates many cellular processes. Given the central role of PP2A in regulating diverse …
regulates many cellular processes. Given the central role of PP2A in regulating diverse …
[HTML][HTML] Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy
J Pan, L Zhou, C Zhang, Q Xu, Y Sun - Signal transduction and targeted …, 2022 - nature.com
Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …
Regulation of the phosphoprotein phosphatase 2A system and its modulation during oxidative stress: A potential therapeutic target?
IS Elgenaidi, JP Spiers - Pharmacology & therapeutics, 2019 - Elsevier
Phosphoprotein phosphatases are of growing interest in the pathophysiology of many
diseases and are often the neglected partner of protein kinases. One family member, PP2A …
diseases and are often the neglected partner of protein kinases. One family member, PP2A …
Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal …
The epidermal growth factor receptor (EGFR) associated with signaling pathways, such as
Janus kinase (JAK)/signal transducer and activator of transcription (STAT), plays an …
Janus kinase (JAK)/signal transducer and activator of transcription (STAT), plays an …
[HTML][HTML] Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progression
Background Triple-negative breast cancer (TNBC) remains difficult to be targeted. SET and
cancerous inhibitor of protein phosphatase 2A (CIP2A) are intrinsic protein-interacting …
cancerous inhibitor of protein phosphatase 2A (CIP2A) are intrinsic protein-interacting …
[HTML][HTML] Redox inhibition of protein phosphatase PP2A: Potential implications in oncogenesis and its progression
D Raman, S Pervaiz - Redox Biology, 2019 - Elsevier
Cellular processes are dictated by the active signaling of proteins relaying messages to
regulate cell proliferation, apoptosis, signal transduction and cell communications. An …
regulate cell proliferation, apoptosis, signal transduction and cell communications. An …
[HTML][HTML] MicroRNA‑383‑5p acts as a prognostic marker and inhibitor of cell proliferation in lung adenocarcinoma by cancerous inhibitor of protein phosphatase 2A
S Zhao, X Gao, S Zang, Y Li, X Feng… - Oncology …, 2017 - spandidos-publications.com
Lung cancer is the leading cause of cancer‑associated mortality worldwide. MicroRNAs
(miRNAs/miRs) serve a role in the occurrence and development of lung cancer. The aim of …
(miRNAs/miRs) serve a role in the occurrence and development of lung cancer. The aim of …
[HTML][HTML] Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer
CP Nader, A Cidem, NM Verrills, AJ Ammit - Respiratory Research, 2019 - Springer
Lung cancer (LC) has the highest relative risk of development as a comorbidity of chronic
obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic …
obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic …