Alternative splicing and related RNA binding proteins in human health and disease

Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Ascites exosomal lncRNA PLADE enhances platinum sensitivity by inducing R-loops in ovarian cancer

H Liu, S Deng, X Yao, Y Liu, L Qian, Y Wang, T Zhang… - Oncogene, 2024 - nature.com
Cisplatin resistance is a major cause of therapeutic failure in patients with high-grade serous
ovarian cancer (HGSOC). Long noncoding RNAs (lncRNAs) have emerged as key …

[HTML][HTML] RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5ʹ-untranslated region

Y Yao, H Sun, Y Chen, L Tian, D Huang, C Liu, Y Zhou… - Antiviral Research, 2023 - Elsevier
SARS-CoV-2 is a betacoronavirus with single-stranded positive-sense RNA, which is a
serious global threat to human health. Understanding the molecular mechanism of viral …

RNA-Binding Proteins in Breast Cancer: Biological Implications and Therapeutic Opportunities

S Wang, H Sun, G Chen, C Wu, B Sun, J Lin… - Critical Reviews in …, 2024 - Elsevier
RNA-binding proteins (RBPs) refer to a class of proteins that participate in alternative
splicing, RNA stability, polyadenylation, localization and translation of RNAs, thus regulating …

IGF2BP3 enhances lipid metabolism in cervical cancer by upregulating the expression of SCD

C Han, C Hu, T Liu, Y Sun, F Hu, Y He, J Zhang… - Cell Death & …, 2024 - nature.com
Cervical cancer (CC) is the most common gynecologic malignancy, which seriously
threatens the health of women. Lipid metabolism is necessary for tumor proliferation and …

Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response

MR Murphy, A Ramadei, A Doymaz… - Nucleic Acids …, 2023 - academic.oup.com
Alternative Polyadenylation (APA) is an emerging mechanism for dynamic changes in gene
expression. Previously, we described widespread APA occurrence in introns during the DNA …

RNA Binding Protein PTBP1 Promotes the Metastasis of Gastric Cancer by Stabilizing PGK1 mRNA

X Wang, C Liang, S Wang, Q Ma, X Pan, A Ran, C Qin… - Cells, 2024 - mdpi.com
Gastric cancer (GC) is the most common type of malignant tumor within the gastrointestinal
tract, and GC metastasis is associated with poor prognosis. Polypyrimidine tract binding …

[HTML][HTML] Oncogenic and immunological values of RBM34 in osteosarcoma and its pan-cancer analysis

W Zhang, R He, W Cao, D Li, Q Zheng… - American Journal of …, 2023 - ncbi.nlm.nih.gov
RNA binding proteins (RBPs) are increasingly recognized as potential factors influencing
the advancement, prognostication, and immune response in various solid tumors …

Exposure to micron-grade silica particles triggers pulmonary fibrosis through cell-to-cell delivery of exosomal miR-107

J Xia, D Wang, W Guo, Y Pei, L Zhang, L Bao… - International Journal of …, 2024 - Elsevier
Long-term exposure to inhalable silica particles may lead to severe systemic pulmonary
disease, such as silicosis. Exosomes have been demonstrated to dominate the …

[HTML][HTML] Role of the RNA-binding protein family in gynecologic cancers

L Hao, J Zhang, Z Liu, Z Zhang, T Mao… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Gynecological cancers pose a threat to women's health. Although early-stage gynecological
cancers show good outcomes after standardized treatment, the prognosis of patients with …