Oral nanomedicine: challenges and opportunities

B Deng, S Liu, Y Wang, B Ali, N Kong, T Xie… - Advanced …, 2024 - Wiley Online Library
Compared to injection administration, oral administration is free of discomfort, wound
infection, and complications and has a higher compliance rate for patients with diverse …

Marine biomaterials in biomedical nano/micro-systems

Y Wang, L Chen, Y Wang, X Wang, D Qian… - Journal of …, 2023 - Springer
Marine resources in unique marine environments provide abundant, cost-effective natural
biomaterials with distinct structures, compositions, and biological activities compared to …

Engineering the intestinal lymphatic transport of oral nanoparticles to educate macrophages for cancer combined immunotherapy

L Xu, S Weng, S Li, K Wang, Y Shen, Y Xu, C Tang… - ACS …, 2023 - ACS Publications
The effectiveness of the commonly used therapy is low for treating triple-negative breast
cancer (TNBC). Macrophages, accounting for up to 50% of the TNBC tumor mass, are …

Fluorocarbon modified chitosan to enable transdermal immunotherapy for melanoma treatment

Q Zhuang, T Chao, Y Wu, T Wei, J Ren, Z Cao, R Peng… - Small, 2023 - Wiley Online Library
Despite the rapid development of the immune checkpoint blockade (ICB) in melanoma
treatment, the immunosuppressive tumor microenvironment (TME) still hinders the efficacy of …

Lipid-and polymer-based nanocarrier platforms for cancer vaccine delivery

S Sunoqrot, SA Abdel Gaber, R Abujaber… - ACS Applied Bio …, 2024 - ACS Publications
Cancer immunotherapy has gained popularity in recent years in the search for effective
treatment modalities for various malignancies, particularly those that are resistant to …

Systemic delivery of proteins using novel peptides via the sublingual route

J Wu, N Jones, L Hohenwarter, F Zhao, V Chan… - Journal of Controlled …, 2024 - Elsevier
Therapeutic proteins often require needle-based injections, which compromise medication
adherence especially for those with chronic diseases. Sublingual administration provides a …

Functional chitosan and its derivative-related drug delivery systems for nano-therapy: recent advances

Z Wang, F Yu, F Hu - Pharmaceutics, 2024 - mdpi.com
In the struggle against diseases, the development of nano-therapy has certainly been a
tremendous progression owing to the various superiority, and chitosan is no doubt a kind of …

Transmucosal delivery of nasal nanovaccines enhancing mucosal and systemic immunity

Y Xu, X Yan, T Wei, M Chen, J Zhu, J Gao, B Liu… - Nano Letters, 2023 - ACS Publications
Intranasal vaccines can induce protective immune responses at the mucosa surface
entrance, preventing the invasion of respiratory pathogens. However, the nasal barrier …

Progress in chitin/chitosan and their derivatives for biomedical applications: Where we stand

L Mu, L Wu, S Wu, Q Ye, Z Zhong - Carbohydrate Polymers, 2024 - Elsevier
Chitin and its deacetylated form, chitosan, have demonstrated remarkable versatility in the
realm of biomaterials. Their exceptional biocompatibility, antibacterial properties, pro-and …

Oral mitochondrial transplantation using nanomotors to treat ischaemic heart disease

Z Wu, L Chen, W Guo, J Wang, H Ni, J Liu… - Nature …, 2024 - nature.com
Mitochondrial transplantation is an important therapeutic strategy for restoring energy supply
in patients with ischaemic heart disease (IHD); however, it is limited by the invasiveness of …