Bacterial multidrug efflux pumps: much more than antibiotic resistance determinants
Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all
microorganisms. With few exceptions, they are chromosomally encoded and present a …
microorganisms. With few exceptions, they are chromosomally encoded and present a …
Efflux pump inhibitors of clinically relevant multidrug resistant bacteria
A Lamut, L Peterlin Mašič, D Kikelj… - Medicinal Research …, 2019 - Wiley Online Library
Bacterial infections are an increasingly serious issue worldwide. The inability of existing
therapies to treat multidrug‐resistant pathogens has been recognized as an important …
therapies to treat multidrug‐resistant pathogens has been recognized as an important …
Intrinsic, adaptive and acquired antimicrobial resistance in Gram-negative bacteria
Gram-negative bacteria are responsible for a large proportion of antimicrobial-resistant
infections in humans and animals. Among this class of bacteria are also some of the most …
infections in humans and animals. Among this class of bacteria are also some of the most …
[HTML][HTML] Antibiotic potentiators against multidrug-resistant bacteria: discovery, development, and clinical relevance
Antimicrobial resistance in clinically important microbes has emerged as an unmet
challenge in global health. Extensively drug-resistant bacterial pathogens have cropped up …
challenge in global health. Extensively drug-resistant bacterial pathogens have cropped up …
[HTML][HTML] RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition
H Venter, R Mowla, T Ohene-Agyei, S Ma - Frontiers in microbiology, 2015 - frontiersin.org
Drug efflux protein complexes confer multidrug resistance on bacteria by transporting a wide
spectrum of structurally diverse antibiotics. Moreover, organisms can only acquire resistance …
spectrum of structurally diverse antibiotics. Moreover, organisms can only acquire resistance …
[HTML][HTML] Inhibiting bacterial drug efflux pumps via phyto-therapeutics to combat threatening antimicrobial resistance
Antibiotics, once considered the lifeline for treating bacterial infections, are under threat due
to the emergence of threatening antimicrobial resistance (AMR). These drug-resistant …
to the emergence of threatening antimicrobial resistance (AMR). These drug-resistant …
Drug efflux pump inhibitors: a promising approach to counter multidrug resistance in Gram-negative pathogens by targeting AcrB protein from AcrAB-TolC multidrug …
R Alenazy - Biology, 2022 - mdpi.com
Simple Summary Multidrug-resistant bacterial infections, especially that caused by Gram-
negative bacteria, have posed serious health issues worldwide. Bacteria have different …
negative bacteria, have posed serious health issues worldwide. Bacteria have different …
Update on the discovery of efflux pump inhibitors against critical priority Gram-negative bacteria
N Compagne, A Vieira Da Cruz, RT Müller… - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR) has become a major problem in public health leading to an
estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and …
estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and …
Phytochemicals: a promising weapon in the arsenal against antibiotic-resistant bacteria
B Khameneh, NAM Eskin, M Iranshahy… - Antibiotics, 2021 - mdpi.com
The extensive usage of antibiotics and the rapid emergence of antimicrobial-resistant
microbes (AMR) are becoming important global public health issues. Many solutions to …
microbes (AMR) are becoming important global public health issues. Many solutions to …
Effectiveness of efflux pump inhibitors as biofilm disruptors and resistance breakers in gram-negative (ESKAPEE) bacteria
Antibiotic resistance represents a significant threat to the modern healthcare provision. The
ESKAPEE pathogens (Enterococcus faecium., Staphylococcus aureus, Klebsiella …
ESKAPEE pathogens (Enterococcus faecium., Staphylococcus aureus, Klebsiella …