[HTML][HTML] B lymphoblastic leukemia/lymphoma: new insights into genetics, molecular aberrations, subclassification and targeted therapy
X Zhang, P Rastogi, B Shah, L Zhang - Oncotarget, 2017 - ncbi.nlm.nih.gov
B lymphoblastic leukemia/lymphoma (B-ALL) is a clonal hematopoietic stem cell neoplasm
derived from B-cell progenitors, which mostly occurs in children and adolescents and is …
derived from B-cell progenitors, which mostly occurs in children and adolescents and is …
[HTML][HTML] Clinical use of SNP-microarrays for the detection of genome-wide changes in haematological malignancies
NK Berry, RJ Scott, P Rowlings, AK Enjeti - Critical reviews in oncology …, 2019 - Elsevier
Single nucleotide polymorphism (SNP) microarrays are commonly used for the clinical
investigation of constitutional genomic disorders; however, their adoption for investigating …
investigation of constitutional genomic disorders; however, their adoption for investigating …
[HTML][HTML] Digital multiplex ligation-dependent probe amplification for detection of key copy number alterations in T-and B-cell lymphoblastic leukemia
A Benard-Slagter, I Zondervan, K de Groot… - The Journal of Molecular …, 2017 - Elsevier
Recurrent and clonal genetic alterations are characteristic of different subtypes of T-and B-
cell lymphoblastic leukemia (ALL), and several subtypes are strong independent predictors …
cell lymphoblastic leukemia (ALL), and several subtypes are strong independent predictors …
[HTML][HTML] PAX5 fusion genes in acute lymphoblastic leukemia: A literature review
FM Fouad, JI Eid - Medicine, 2023 - journals.lww.com
Acute lymphoblastic leukemia (ALL) is a common cancer affecting children worldwide. The
development of ALL is driven by several genes, some of which can be targeted for treatment …
development of ALL is driven by several genes, some of which can be targeted for treatment …
High occurrence of CRLF2 abnormalities in Mexican children with B-cell acute lymphoblastic leukemia
M del Rocío Juárez-Velázquez, DL Moreno-Lorenzana… - Cytokine, 2022 - Elsevier
Abstract The P2RY8-CRLF2 and IGH-CRLF2 rearrangements induce the overexpression of
cytokine receptor-like factor 2 (CRLF2) and have been associated with relapse and poor …
cytokine receptor-like factor 2 (CRLF2) and have been associated with relapse and poor …
Copy number profiling of adult relapsed B‐cell precursor acute lymphoblastic leukemia reveals potential leukemia progression mechanisms
J Ribera, L Zamora, M Morgades… - Genes …, 2017 - Wiley Online Library
The outcome of relapsed adult acute lymphoblastic leukemia (ALL) remains dismal despite
new therapeutic approaches. Previous studies analyzing relapse samples have shown a …
new therapeutic approaches. Previous studies analyzing relapse samples have shown a …
The Role of the JAK–STAT Pathway in Childhood B-Cell Acute Lymphoblastic Leukemia
KJ Ziętara, K Wróblewska, M Zajączkowska… - International Journal of …, 2024 - mdpi.com
B-cell lymphoblastic leukemia is a hematologic neoplasm that poses a serious health
concern in childhood. Genetic aberrations, such as mutations in the genes IL-7, IL7R, JAK1 …
concern in childhood. Genetic aberrations, such as mutations in the genes IL-7, IL7R, JAK1 …
Panobinostat (LBH589) increase survival in adult xenografic model of acute lymphoblastic leukemia with t (4; 11) but promotes antagonistic effects in combination with …
DA Moreno, HLR Junior, ABA Laranjeira… - Medical Oncology, 2022 - Springer
Patients diagnosed with acute lymphoblastic leukemia (ALL) bearing t (4; 11)/MLL-AF4 have
aggressive clinical features, poor prognosis and there is an urgent need for new therapies to …
aggressive clinical features, poor prognosis and there is an urgent need for new therapies to …
[HTML][HTML] SRC/ABL inhibition disrupts CRLF2-driven signaling to induce cell death in B-cell acute lymphoblastic leukemia
Children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) overexpressing the
CRLF2 gene (hiCRLF2) have poor prognosis. CRLF2 protein overexpression leads to …
CRLF2 gene (hiCRLF2) have poor prognosis. CRLF2 protein overexpression leads to …
IKZF1 alterations and expression of CRLF2 predict prognosis in adult Chinese patients with B-cell precursor acute lymphoblastic leukemia
Q Fang, X Zhao, Q Li, Y Li, K Liu, K Tang… - Leukemia & …, 2017 - Taylor & Francis
Abstract Acute Lymphoblastic Leukemia (ALL) is a common hematological malignancy in
children, with a prognosis much worse in adults. The molecular characterization of ALL and …
children, with a prognosis much worse in adults. The molecular characterization of ALL and …