Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Executive summary Inspired by unprecedented improvements in human health and
development in recent decades, our world has embarked on a quest that only a generation …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

In 2015, a large human immunodeficiency virus (HIV) outbreak occurred among persons
who inject drugs (PWID) in Indiana. During 2016–2019, additional outbreaks among PWID …

The opioid epidemic is one of the greatest public health problems that the USA faces. Opioid
overdose death rates have increased steadily for more than a decade and doubled in 2013 …

Background There are an estimated 3.2 million women who inject drugs worldwide,
constituting 20% of all people who inject drugs. The limited data that are available suggest …

Background People who inject drugs have a high prevalence of hepatitis C virus (HCV) and
significant disease associated with drug use; however, HCV treatment often occurs in …

Third-party materials. If you wish to reuse material from this work that is attributed to a third
party, such as tables, figures or images, it is your responsibility to determine whether …

In 2006, WHO set forth its vision for a public health approach to delivering antiretroviral
therapy. This approach has been broadly adopted in resource-poor settings and has …

Aims To estimate whether opioid substitution treatment (OST) with buprenorphine or
methadone is associated with a greater reduction in the risk of all‐cause mortality (ACM) …