Brain circuits for pain and its treatment
Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
Heart rate variability and slow-paced breathing: when coherence meets resonance
C Sevoz-Couche, S Laborde - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Clinical research on the beneficial effects induced by slow-paced breathing has been
increasingly extended in the past twenty years. Improvements in cardiovascular functioning …
increasingly extended in the past twenty years. Improvements in cardiovascular functioning …
[PDF][PDF] The molecular basis of drug addiction: linking epigenetic to synaptic and circuit mechanisms
EJ Nestler, C Lüscher - Neuron, 2019 - cell.com
Addiction is a disease in which, after a period of recreational use, a subset of individuals
develops compulsive use that does not stop even in light of major negative consequences …
develops compulsive use that does not stop even in light of major negative consequences …
Sleep, pain, and cognition: modifiable targets for optimal perioperative brain health
The prevention of perioperative neurocognitive disorders is a priority for patients, families,
clinicians, and researchers. Given the multiple risk factors present throughout the …
clinicians, and researchers. Given the multiple risk factors present throughout the …
The role of the insular cortex in pain
C Labrakakis - International Journal of Molecular Sciences, 2023 - mdpi.com
The transition from normal to chronic pain is believed to involve alterations in several brain
areas that participate in the perception of pain. These plastic changes are then responsible …
areas that participate in the perception of pain. These plastic changes are then responsible …
The emerging role of the BDNF-TrkB signaling pathway in the modulation of pain perception
The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain
transmission both in peripheral and central nervous system (CNS). Despite evidence of a …
transmission both in peripheral and central nervous system (CNS). Despite evidence of a …
Elevated prelimbic cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors associated with chronic pain
F Gao, J Huang, GB Huang, QL You… - The Journal of …, 2023 - Am Soc Clin Investig
Chronic pain can cause both hyperalgesia and anxiety symptoms. However, how the two
components are encoded in the brain remains unclear. The prelimbic cortex (PrL), a critical …
components are encoded in the brain remains unclear. The prelimbic cortex (PrL), a critical …
Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding
Opioid-induced respiratory depression (OIRD) represents the primary cause of death
associated with therapeutic and recreational opioid use. Within the United States, the rate of …
associated with therapeutic and recreational opioid use. Within the United States, the rate of …
Lateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety
D Wang, X Pan, Y Zhou, Z Wu, K Ren, H Liu… - Molecular …, 2023 - nature.com
Pain and anxiety comorbidities are a common health problem, but the neural mechanisms
underlying comorbidity remain unclear. We propose that comorbidity implies that similar …
underlying comorbidity remain unclear. We propose that comorbidity implies that similar …
Circadian rhythms and pain
The goal of this review is to provide a perspective on the nature and importance of the
relationship between the circadian and pain systems. We provide: 1) An overview of the …
relationship between the circadian and pain systems. We provide: 1) An overview of the …