Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

Clinical research on the beneficial effects induced by slow-paced breathing has been
increasingly extended in the past twenty years. Improvements in cardiovascular functioning …

Addiction is a disease in which, after a period of recreational use, a subset of individuals
develops compulsive use that does not stop even in light of major negative consequences …

The prevention of perioperative neurocognitive disorders is a priority for patients, families,
clinicians, and researchers. Given the multiple risk factors present throughout the …

The transition from normal to chronic pain is believed to involve alterations in several brain
areas that participate in the perception of pain. These plastic changes are then responsible …

The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain
transmission both in peripheral and central nervous system (CNS). Despite evidence of a …

Chronic pain can cause both hyperalgesia and anxiety symptoms. However, how the two
components are encoded in the brain remains unclear. The prelimbic cortex (PrL), a critical …

Opioid-induced respiratory depression (OIRD) represents the primary cause of death
associated with therapeutic and recreational opioid use. Within the United States, the rate of …

Pain and anxiety comorbidities are a common health problem, but the neural mechanisms
underlying comorbidity remain unclear. We propose that comorbidity implies that similar …

The goal of this review is to provide a perspective on the nature and importance of the
relationship between the circadian and pain systems. We provide: 1) An overview of the …